Synthesis and antitumor evaluation of methyl spongoate analogs

doi:10.1016/j.steroids.2010.08.002

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	Synthesis and antitumor evaluation of methyl spongoate analogs
	Jiang, Cheng-Shi 1; Huang, Cai-Guo 2; Feng, Bo 2; Li, Jia1 ; Gong, Jing-Xu 1; Kurtan, Tibor 3; Guo, Yue-Wei1
刊名	STEROIDS
	2010-12-12
卷号	75 期号:13-14 页码:1153-1163
关键词	Synthesis Methyl spongoate analogs Cytotoxicity Michael acceptor
ISSN号	0039-128X
DOI	10.1016/j.steroids.2010.08.002
文献子类	Article
英文摘要	A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 and NCl-H460 tumor cell lines. The pharmacological results confirmed that the alpha,beta-unsaturated carbonyl moiety, a Michael acceptor in ring A, plays a pivotal role in the cytotoxic effect of these derivatives. The compiled pharmacological data may be useful for the design of novel analogous anticancer drugs. (C) 2010 Elsevier Inc. All rights reserved.
资助项目	National ST Major Project[2009ZX09301-001] ; National ST Major Project[2009ZX09103-060] ; National Science Foundation of China[30730108] ; National Science Foundation of China[20721003] ; STCSM[09ZR1438000] ; STCSM[10540702900] ; CAS[SIMM0907KF-09] ; TRF-NSFC[20911140471] ; Hungarian-Chinese Intergovernment S&T Cooperation Programme[00000000]
WOS关键词	ALPHA,BETA-UNSATURATED CARBONYL SYSTEMS ; CYTOTOXIC AGENTS ; SOFT CORAL ; ACID ; STEROIDS ; KETONES ; DERIVATIVES ; APOPTOSIS ; BINDING ; CANCER
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000283613700015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278690]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Gong, Jing-Xu
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Second Mil Med Univ, Shanghai 200433, Peoples R China; 3.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary
推荐引用方式 GB/T 7714	Jiang, Cheng-Shi,Huang, Cai-Guo,Feng, Bo,et al. Synthesis and antitumor evaluation of methyl spongoate analogs[J]. STEROIDS,2010,75(13-14):1153-1163.
APA	Jiang, Cheng-Shi.,Huang, Cai-Guo.,Feng, Bo.,Li, Jia.,Gong, Jing-Xu.,...&Guo, Yue-Wei.(2010).Synthesis and antitumor evaluation of methyl spongoate analogs.STEROIDS,75(13-14),1153-1163.
MLA	Jiang, Cheng-Shi,et al."Synthesis and antitumor evaluation of methyl spongoate analogs".STEROIDS 75.13-14(2010):1153-1163.