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	Synthesis and antitumor activity of novel salvicine analogues
	Deng, Fei1; Lu, Jin Jian1; Liu, Hong Ying2; Lin, Li Ping1; Ding, Jian1; Zhang, Jin Sheng1
刊名	CHINESE CHEMICAL LETTERS
	2011-01
卷号	22期号:1页码:25-28
关键词	Saprorthoquinone Salvicine Antitumor Structural modification
ISSN号	1001-8417
DOI	10.1016/j.cclet.2010.07.009
文献子类	Article
英文摘要	Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase II inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells. (C) 2010 Fei Deng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
WOS关键词	PRIONITIS
WOS研究方向	Chemistry
语种	英语
CSCD记录号	CSCD:4122330
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000286551700007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278632]
专题	天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室
通讯作者	Deng, Fei
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.NW A&F Univ, Coll Life Sci, Yangling 712100, Peoples R China
推荐引用方式 GB/T 7714	Deng, Fei,Lu, Jin Jian,Liu, Hong Ying,et al. Synthesis and antitumor activity of novel salvicine analogues[J]. CHINESE CHEMICAL LETTERS,2011,22(1):25-28.
APA	Deng, Fei,Lu, Jin Jian,Liu, Hong Ying,Lin, Li Ping,Ding, Jian,&Zhang, Jin Sheng.(2011).Synthesis and antitumor activity of novel salvicine analogues.CHINESE CHEMICAL LETTERS,22(1),25-28.
MLA	Deng, Fei,et al."Synthesis and antitumor activity of novel salvicine analogues".CHINESE CHEMICAL LETTERS 22.1(2011):25-28.

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