Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability

doi:10.1093/glycob/cwr020

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability
	Li, Jing1 ; Dai, Gong 1; Cheng, Ya-Bin 1; Qi, Xin 1; Geng, Mei-Yu1,2
刊名	GLYCOBIOLOGY
	2011-08
卷号	21 期号:8 页码:1010-1018
关键词	adhesion FGFR migration NCAM PSA
ISSN号	0959-6658
DOI	10.1093/glycob/cwr020
文献子类	Article
英文摘要	Polysialic acid (PSA), a carbohydrate polymer mainly present in the neural cell adhesion molecule (NCAM), promotes neural plasticity; however, its mode of action in tumor malignancy remains largely unknown. In this study, we investigated the influence of polysialylation on cell migration. PSA consistently promoted cell migration on different extracellular matrices (ECMs) but differentially affected cell adhesion. All of these actions were reversed by endo-N-acetylneuraminidase treatment, and PSA-driven migration was inhibited by the specific fibroblast growth factor receptor (FGFR) inhibitor Su5402. Consistent with this latter observation, PSA-stimulated migration on different ECMs was paralleled by activation of the FGFR and its downstream signaling components, PLC-gamma, focal adhesion kinase and extracellular signal-regulated kinase 1/2. In contrast, the pattern of p59(fyn) activation correlated with differential adhesion to different ECMs. Collectively, these results indicate that PSA-conjugated NCAM potentiates signal transduction by the FGFR pathway and thereby enhances cell migration independent of adhesion capability, providing additional insights into the role of PSA in cancer development.
资助项目	Program for Changjiang Scholars and Innovative Research Team in University[IRT0944] ; Natural Science Foundation of China for Distinguished Young Scholars[30725046] ; State Plan for High-Tech Research and Development of China[2007AA09Z405]
WOS关键词	POLYSIALIC ACID EXPRESSION ; NERVOUS-SYSTEM ; BREAST-CANCER ; LUNG-CANCER ; NCAM ; INVASION ; ACTIVATION ; PATHWAYS ; BINDING ; STX
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	OXFORD UNIV PRESS INC
WOS记录号	WOS:000292557600004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278462]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Geng, Mei-Yu
作者单位	1.Ocean Univ China, Sch Med & Pharm, Dept Pharmacol & Glycobiol, Qingdao 266003, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, PR, Peoples R China
推荐引用方式 GB/T 7714	Li, Jing,Dai, Gong,Cheng, Ya-Bin,et al. Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability[J]. GLYCOBIOLOGY,2011,21(8):1010-1018.
APA	Li, Jing,Dai, Gong,Cheng, Ya-Bin,Qi, Xin,&Geng, Mei-Yu.(2011).Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability.GLYCOBIOLOGY,21(8),1010-1018.
MLA	Li, Jing,et al."Polysialylation promotes neural cell adhesion molecule-mediated cell migration in a fibroblast growth factor receptor-dependent manner, but independent of adhesion capability".GLYCOBIOLOGY 21.8(2011):1010-1018.