Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring

doi:10.1111/j.1440-1681.2011.05568.x

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	Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring
	Zhang, Zhi-Yun 1,2; Zeng, Jin-Jing 1,2; Kjaergaard, Marina 3; Guan, Ni 1,2; Raun, Kirsten 3; Nilsson, Cecilia 3; Wang, Ming-Wei1,2
刊名	CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
	2011-09
卷号	38 期号:9 页码:613-622
关键词	bodyweight chocolate fat metabolism fructose maternal supplemental diet metabolic programming rat
ISSN号	0305-1870
DOI	10.1111/j.1440-1681.2011.05568.x
文献子类	Article
英文摘要	1. Consumption of a high-fat and high-energy diet during pregnancy leads to a risk of long-term consequences on fetal development, as well as on the postnatal health of offspring. To investigate the effects of such a diet on fetal programming, we established a high-energy intake pregnant rat model using chocolate and fructose beverage as supplements to a normal chow diet. 2. Pregnant Sprague-Dawley rats were assigned to either chow (control) or a diet supplemented with chocolate and fructose beverage throughout gestation and lactation. The male F(1) pups received normal chow diet after weaning. Physiological or pathological changes in dams and pups (e. g. glucose and lipid metabolism) were evaluated. 3. The results showed that dams offered the high-fat (mainly from chocolate) and high-calorie diet during gestation consumed more energy and gained more weight than chow-fed dams. Over-consumption of chocolate reduced chow intake in dams, leading to low maternal protein supply. As a result, pups from these dams exhibited reduced birth weight that lasted until adulthood. The high-energy diet during lactation led to increased total body fat, as well as impaired liver function, in offspring; thus, the lactational diet is suggested to be a stronger determinant of offspring fat metabolism than gestational diet. 4. The results of the study suggest that over-supply of carbohydrates, such as chocolate and fructose, either during gestation or lactation has a negative impact on the well-being of offspring.
资助项目	CAS[00000000] ; Ministry of Science and Technology of China[2009ZX09302-001]
WOS关键词	HIGH-FAT DIET ; PROTEIN RESTRICTION ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; PREGNANT RATS ; FOOD-INTAKE ; PPAR-ALPHA ; NUTRITION ; OBESITY ; ACID
WOS研究方向	Pharmacology & Pharmacy ; Physiology
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000294563600010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278420]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Wang, Ming-Wei
作者单位	1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Novo Nordisk AS, Diabet Res Unit, Malov, Denmark
推荐引用方式 GB/T 7714	Zhang, Zhi-Yun,Zeng, Jin-Jing,Kjaergaard, Marina,et al. Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2011,38(9):613-622.
APA	Zhang, Zhi-Yun.,Zeng, Jin-Jing.,Kjaergaard, Marina.,Guan, Ni.,Raun, Kirsten.,...&Wang, Ming-Wei.(2011).Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,38(9),613-622.
MLA	Zhang, Zhi-Yun,et al."Effects of a maternal diet supplemented with chocolate and fructose beverage during gestation and lactation on rat dams and their offspring".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 38.9(2011):613-622.