The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone

doi:10.1016/j.bmcl.2012.01.069

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	The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone
	Song, Shao-Xing 1,2; Wu, Ming-Li 1,2; He, Xiao-Peng 1,2; Zhou, Yu-Bo3 ; Sheng, Li 3; Li, Jia3 ; Chen, Guo-Rong 1,2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2012-03-01
卷号	22 期号:5 页码:2030-2032
关键词	Glycolipid Cytotoxicity Mixture MTT Glycosylation
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2012.01.069
文献子类	Article
英文摘要	The anomeric mixture of a series of O-galactolipid derivatives is revealed to be more toxic against several cancer cell lines than their either single component with the pure alpha- or beta-configuration. This interesting phenomenon has been confirmed on pairs of synthesized O-galactosyl anomers bearing length-varied alkyl chains at the lipid end. Furthermore, the most potent mixture was determined inoffensive to a normal cell line tested. (C) 2012 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[21176076] ; National Natural Science Foundation of China[30801405] ; National Basic Research Program of China[2007CB914201] ; Shanghai Science and Technology Community[10410702700] ; Chinese Academy of Sciences[KSCX2-EW-R-15] ; China Postdoctoral Science Foundation[2011M500069]
WOS关键词	CLICK CHEMISTRY ; GLYCOLIPIDS ; PROLIFERATION ; ASSESSMENTS ; GLYCOSIDES ; HYBRIDS ; ANALOGS ; AGENTS
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000300451200039
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278177]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心
通讯作者	He, Xiao-Peng
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Song, Shao-Xing,Wu, Ming-Li,He, Xiao-Peng,et al. The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(5):2030-2032.
APA	Song, Shao-Xing.,Wu, Ming-Li.,He, Xiao-Peng.,Zhou, Yu-Bo.,Sheng, Li.,...&Chen, Guo-Rong.(2012).The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(5),2030-2032.
MLA	Song, Shao-Xing,et al."The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.5(2012):2030-2032.