Improved synthesis of rupintrivir

doi:10.1007/s11426-011-4478-5

	Improved synthesis of rupintrivir
	Lin DaiZong 2; Qian WangKe 3; Hilgenfeld, Rolf 1,2; Jiang HuaLiang2 ; Chen KaiXian2 ; Liu Hong2
刊名	SCIENCE CHINA-CHEMISTRY
	2012-06
卷号	55 期号:6 页码:1101-1107
关键词	rupintrivir AG7088 synthesis
ISSN号	1674-7291
DOI	10.1007/s11426-011-4478-5
文献子类	Article
英文摘要	An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
资助项目	National Natural Science Foundation of China[20872153] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[20720102040] ; National Natural Science Foundation of China[81025017] ; National Basic Research Program of China[2009CB918502] ; Chinese Academy of Sciences[XDA01040305] ; Chinese Academy of Sciences[2010T1S6] ; European Commission[HEALTH-F3-2010-260644]
WOS关键词	RHINOVIRUS PROTEASE INHIBITOR ; STRUCTURE-BASED DESIGN ; BIOLOGICAL EVALUATION ; ENTEROVIRUS 71 ; INTERMEDIATE ; PROTEINASE ; EFFICIENT ; AG7088
WOS研究方向	Chemistry
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000305238400032
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278058]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Liu Hong
作者单位	1.Med Univ Lubeck, Inst Biochem, Ctr Struct & Cell Biol Med, D-23538 Lubeck, Germany 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China;
推荐引用方式 GB/T 7714	Lin DaiZong,Qian WangKe,Hilgenfeld, Rolf,et al. Improved synthesis of rupintrivir[J]. SCIENCE CHINA-CHEMISTRY,2012,55(6):1101-1107.
APA	Lin DaiZong,Qian WangKe,Hilgenfeld, Rolf,Jiang HuaLiang,Chen KaiXian,&Liu Hong.(2012).Improved synthesis of rupintrivir.SCIENCE CHINA-CHEMISTRY,55(6),1101-1107.
MLA	Lin DaiZong,et al."Improved synthesis of rupintrivir".SCIENCE CHINA-CHEMISTRY 55.6(2012):1101-1107.