Diverse Mechanisms of Antidialbetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice

doi:10.1021/jf3024535

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	Diverse Mechanisms of Antidialbetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice
	Chen, Liang 2; Sun, Peng 1,2; Wang, Ting 1; Chen, Kaixian1,2 ; Jia, Qi 2; Wang, Heyao1 ; Li, Yiming 2
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2012-09-12
卷号	60 期号:36 页码:9144-9150
关键词	Cinnamom Cinnamomum cassia Cinnamomum tamala diabetes mellitus procyanidin oligomers
ISSN号	0021-8561
DOI	10.1021/jf3024535
文献子类	Article
英文摘要	The procyanidin oligomers are thought to be responsible for the antidiabetic activity of cinnamon. To investigate the hypoglycemic effects of different procyanidin oligomer types, the procyanidin oligomer-rich extracts were prepared from two different cinnamon species. Using high-performance liquid chromatography with purified procyanidin oligomers as reference compounds, we found that the Cinnamomum cassia extract (CC-E) and Cinnamomum tamala extract (CT-E) were rich in B- and A-type procyanidin oligomers, respectively. In the experiment, 8-week-old diabetic (db/db) mice were gavaged with CC-E and CT-E (both 200 mg/kg per day) for 4 weeks. Both CC-E and CT-E exhibited antidiabetic effects. Moreover, histopathological studies of the pancreas, liver, and adipose tissue showed that CC-E promoted lipid accumulation in the adipose tissue and liver, whereas CT-E mainly improved the insulin concentration in the blood and pancreas.
资助项目	National Natural Science Foundation of China (NSFC)[81172951] ; Shanghai TCM Modernization Project of Science and Technology Innovation Action Plan[08DZ1972102] ; Shanghai Institutions of Higher Learning and the Program for Shanghai Key Discipline Establishment of TCM Pharmaceutics[JS050302] ; State Key Laboratory of Drug Research[SIMM1106KF-14]
WOS关键词	ADVANCED GLYCATION ENDPRODUCTS ; INSULIN-RESISTANCE ; DIABETES-MELLITUS ; MEDICINAL-PLANTS ; IN-VIVO ; GLUCOSE ; EXTRACT ; RATS ; PROANTHOCYANIDINS ; POLYPHENOLS
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000308574900047
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277944]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物发现与设计中心天然药物化学研究室
通讯作者	Jia, Qi
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Chen, Liang,Sun, Peng,Wang, Ting,et al. Diverse Mechanisms of Antidialbetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(36):9144-9150.
APA	Chen, Liang.,Sun, Peng.,Wang, Ting.,Chen, Kaixian.,Jia, Qi.,...&Li, Yiming.(2012).Diverse Mechanisms of Antidialbetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(36),9144-9150.
MLA	Chen, Liang,et al."Diverse Mechanisms of Antidialbetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.36(2012):9144-9150.