Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes

doi:10.1021/jo3021105

	Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes
	Sun, Hongpeng 2,3; Zhou, Huayong 2; Khorev, Oleg 1; Jiang, Ruwei 2; Yu, Ting ; Wang, Xin2 ; Du, Yongli 3; Ma, Yi 3; Meng, Tao2 ; Shen, Jingkang 2
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2012-12-07
卷号	77 期号:23 页码:10745-10751
ISSN号	0022-3263
DOI	10.1021/jo3021105
文献子类	Article
英文摘要	An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag2CO3-catalyzed, three-component domino reaction. This in turn will set the stage for a wide application of this useful reaction for the synthesis of structurally diverse polyheterocyclic skeletons containing the imidazo[1,2-a]pyridine privileged structure.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09103-101-026] ; National Natural Science Foundation of China[81001355] ; National Natural Science Foundation of China[81273367]
WOS关键词	BRIDGEHEAD NITROGEN-ATOMS ; MULTICOMPONENT REACTIONS ; COMBINATORIAL SYNTHESIS ; HETEROCYCLIC-COMPOUNDS ; MOLECULAR COMPLEXITY ; DERIVATIVES ; ISOCYANIDES ; CHEMISTRY ; STRATEGIES ; SCAFFOLDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000311926100029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277849]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Meng, Tao
作者单位	1.Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Shandong Polytech Univ, Sch Chem & Pharmaceut Engn, Jinan 250353, Peoples R China;
推荐引用方式 GB/T 7714	Sun, Hongpeng,Zhou, Huayong,Khorev, Oleg,et al. Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes[J]. JOURNAL OF ORGANIC CHEMISTRY,2012,77(23):10745-10751.
APA	Sun, Hongpeng.,Zhou, Huayong.,Khorev, Oleg.,Jiang, Ruwei.,Yu, Ting.,...&Shen, Jingkang.(2012).Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes.JOURNAL OF ORGANIC CHEMISTRY,77(23),10745-10751.
MLA	Sun, Hongpeng,et al."Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a(1),3-Triazaacenaphthylenes".JOURNAL OF ORGANIC CHEMISTRY 77.23(2012):10745-10751.