Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance

doi:10.1523/JNEUROSCI.4790-12.2013

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	Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance
	Zhu, Zhiyuan; Yan, Jianming; Jiang, Wei; Yao, Xin-gang; Chen, Jing; Chen, Lili; Li, Chenjing; Hu, Lihong; Jiang, Hualiang; Shen, Xu
刊名	JOURNAL OF NEUROSCIENCE
	2013-08-07
卷号	33 期号:32 页码:13138-13149
ISSN号	0270-6474
DOI	10.1523/JNEUROSCI.4790-12.2013
文献子类	Article
英文摘要	Alzheimer's disease (AD) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. The beta-amyloid (A beta)-induced neurodegeneration is believed to be the main pathological mechanism of AD, and A beta production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-AD research. Here, we report that the natural product arctigenin from Arctium lappa (L.) can both inhibit A beta production by suppressing beta-site amyloid precursor protein cleavage enzyme 1 expression and promote A beta clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation as investigated in cells and APP/PS1 transgenic AD model mice. Moreover, the results showing that treatment of arctigenin in mice highly decreased A beta formation and senile plaques and efficiently ameliorated AD mouse memory impairment strongly highlight the potential of arctigenin in anti-AD drug discovery.
资助项目	State Key Program of Basic Research of China[2010CB912501] ; National Natural Science Foundation of China[81173105] ; National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[91213306] ; National Natural Science Foundation of China[30925040] ; Shanghai Basic Research Project from the Shanghai Science and Technology Commission[11ZR1444500] ; Shanghai Basic Research Project from the Shanghai Science and Technology Commission[11XD1406100] ; China Postdoctoral Science Foundation[2012M520051]
WOS关键词	ACTIVATED PROTEIN-KINASE ; MOUSE MODEL ; THERAPEUTIC TARGET ; BACE1 EXPRESSION ; MAMMALIAN TARGET ; CELL-DEATH ; LIFE-SPAN ; IN-VITRO ; AUTOPHAGY ; AMPK
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:000322823300023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277508]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室药物发现与设计中心药理学第三研究室
通讯作者	Shen, Xu
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Zhiyuan,Yan, Jianming,Jiang, Wei,et al. Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance[J]. JOURNAL OF NEUROSCIENCE,2013,33(32):13138-13149.
APA	Zhu, Zhiyuan.,Yan, Jianming.,Jiang, Wei.,Yao, Xin-gang.,Chen, Jing.,...&Shen, Xu.(2013).Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance.JOURNAL OF NEUROSCIENCE,33(32),13138-13149.
MLA	Zhu, Zhiyuan,et al."Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both beta-Amyloid Production and Clearance".JOURNAL OF NEUROSCIENCE 33.32(2013):13138-13149.