Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease

doi:10.1038/aps.2013.104

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	Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease
	Jiang, Ru-wei; Du, Xiao-guang; Zhang, Xuan; Wang, Xin; Hu, Ding-yu; Meng, Tao; Chen, Yue-lei; Geng, Mei-yu; Shen, Jing-kang
刊名	ACTA PHARMACOLOGICA SINICA
	2013-12
卷号	34 期号:12 页码:1585-1591
关键词	Alzheimer's disease A beta peptide oligosaccharide beta-(1,4)-D-mannan oligomannurarate 971 alzhemed neuroprotection medicinal chemistry
ISSN号	1671-4083
DOI	10.1038/aps.2013.104
文献子类	Article
英文摘要	Aim: Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against A beta peptide toxicity in vitro. Methods: The sulfoxide method was applied to synthesize the derivatives. SH-SY5Y human neuroblastoma cells were treated with A beta(1-40) (2 mu mol/L), and the cell viability was detected using a CCK8 assay. Results: A series of beta-(1,4)-D-mannosyl oligosaccharide, ranging from the disaccharide to the hexasaccharide, were synthesized. Addition of 10 mu mol/L beta-(1,4)-D-mannobiose 6, beta-(1,4)-D-mannotriose 9 or beta-(1,4)-D-mannotetraose 12 in SH-SY5Y cells significantly attenuated A beta 1-40-induced toxicity. The efficacies were similar to those caused by 10 mu mol/L oligomannurarate 971 or alzhemed. Other oligosaccharides including oligomaltoses and oligocelluloses were less active. Conclusion: Synthetic homogeneous short chain beta-(1,4)-D-mannans shows neuroprotective effect against A beta peptide toxicity similar to that of heterogeneous oligomannurarate 971 and alzhemed.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program," China[2012ZX09301001]
WOS关键词	DIRECT CHEMICAL-SYNTHESIS ; BETA-MANNOPYRANOSIDES ; SULFOXIDE METHOD ; POLYSACCHARIDE ; PROTEIN
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5003750
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000328268600013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277353]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室
通讯作者	Geng, Mei-yu
作者单位	Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Ru-wei,Du, Xiao-guang,Zhang, Xuan,et al. Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease[J]. ACTA PHARMACOLOGICA SINICA,2013,34(12):1585-1591.
APA	Jiang, Ru-wei.,Du, Xiao-guang.,Zhang, Xuan.,Wang, Xin.,Hu, Ding-yu.,...&Shen, Jing-kang.(2013).Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease.ACTA PHARMACOLOGICA SINICA,34(12),1585-1591.
MLA	Jiang, Ru-wei,et al."Synthesis and bioassay of beta-(1,4)-D-mannans as potential agents against Alzheimer's disease".ACTA PHARMACOLOGICA SINICA 34.12(2013):1585-1591.