K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

doi:10.1038/ni.2810

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	K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5
	Harikumar, Kuzhuvelil B.3,4; Yester, Jessie W.3,4; Surace, Michael J.3,4; Oyeniran, Clement 3,4; Price, Megan M.3,4; Huang, Wei-Ching 3,4; Hait, Nitai C.3,4; Allegood, Jeremy C.3,4; Yamada, Akimitsu 3,4,5; Kong, Xiangqian 1
刊名	NATURE IMMUNOLOGY
	2014-03
卷号	15 期号:3 页码:231-238
ISSN号	1529-2908
DOI	10.1038/ni.2810
文献子类	Article
英文摘要	Although interleukin 1 (IL-1) induces expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in immune and inflammatory responses and mechanisms of its activation remain elusive. Here we found that IRF1 was essential for IL-1-induced expression of the chemokines CXCL10 and CCL5, which recruit mononuclear cells into sites of sterile inflammation. Newly synthesized IRF1 acquired Lys63 (K63)-linked polyubiquitination mediated by the apoptosis inhibitor cIAP2 that was enhanced by the bioactive lipid SIP. In response to IL-1, cIAP2 and the sphingosine kinase SphK1 (the enzyme that generates S1P) formed a complex with IRF1, which led to its activation. Thus, IL-1 triggered a hitherto unknown signaling cascade that controlled the induction of IRF1-dependent genes that encode molecules important for sterile inflammation.
资助项目	US National Institutes of Health[1R01AI093718] ; US National Institutes of Health[5R37GM043880] ; US National Institutes of Health[1U19AI077435] ; US National Institutes of Health[R01CA160688] ; US National Institutes of Health[5P30NS047463] ; US National Institutes of Health[P30CA16059] ; National Natural Science Foundation of China[91029704]
WOS关键词	NF-KAPPA-B ; REGULATORY FACTOR-I ; SYNERGISTIC ACTIVATION ; GENES ; KINASE ; TRAF2 ; INTERLEUKIN-1 ; EXPRESSION ; APOPTOSIS ; PATHWAY
WOS研究方向	Immunology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000331683100008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277177]
专题	药物发现与设计中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Kordula, Tomasz
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 2.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA 3.Virginia Commonwealth Univ, Dept Biochem & Mol Biol, Sch Med, Richmond, VA 23284 USA; 4.Virginia Commonwealth Univ, Massey Canc Ctr, Sch Med, Richmond, VA USA; 5.Virginia Commonwealth Univ, Dept Surg, Sch Med, Richmond, VA USA; 6.Washington Univ, Sch Med, Dept Med, Dept Mol Microbiol, St Louis, MO 63110 USA;
推荐引用方式 GB/T 7714	Harikumar, Kuzhuvelil B.,Yester, Jessie W.,Surace, Michael J.,et al. K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5[J]. NATURE IMMUNOLOGY,2014,15(3):231-238.
APA	Harikumar, Kuzhuvelil B..,Yester, Jessie W..,Surace, Michael J..,Oyeniran, Clement.,Price, Megan M..,...&Kordula, Tomasz.(2014).K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.NATURE IMMUNOLOGY,15(3),231-238.
MLA	Harikumar, Kuzhuvelil B.,et al."K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5".NATURE IMMUNOLOGY 15.3(2014):231-238.