A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada

doi:10.1016/j.phytochem.2014.03.021

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	A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada
	Yu, Xiao-Qing 1; He, Wen-Fei 2; Liu, Ding-Quan 1; Feng, Mei-Tang 1; Fang, Yi 1; Wang, Bin 1; Feng, Li-Hua 1; Guo, Yue-Wei2 ; Mao, Shui-Chun 1,3
刊名	PHYTOCHEMISTRY
	2014-07
卷号	103 页码:162-170
关键词	Laurencia okamurai Laurencia Rhodomelaceae seco-Laurokamurane sesquiterpene Laurokamurane sesquiterpene Laurane sesquiterpene Bisabolane sesquiterpene Antifungal activity Cytotoxicity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2014.03.021
文献子类	Article
英文摘要	A ring-cleaved sesquiterpene, named seco-laurokamurone, four laurane-type sesquiterpenes, laurepoxyene, 3 beta-hydroperoxyaplysin, 3 alpha-hydroperoxy-3-epiaplysin, and 8,10-dibromoisoaplysin, one laurokamurane-type sesquiterpene, laurokamurene D, and one bisabolane-type sesquiterpene, (5S)-5acetoxy-beta-bisabolene, have been isolated from a re-collection of the red alga Laurencia okamurai Yamada, together with six other known sesquiterpenes. Their structures, including relative configuration, were elucidated by detailed analysis of spectroscopic data, and by comparison with data for related known compounds. In addition, on the basis of chemical conversions, degradation results, and biogenetic considerations, the absolute configurations of several of these compounds were also tentatively proposed. seco-Laurokamurone possesses an unprecedented carbon skeleton, formed from an oxidative cleavage of the laurokamurane skeleton, and laurokamurene D represents the fourth example of a laurokamurane-type sesquiterpene from a natural source. The in vitro antifungal activity of many of these compounds was evaluated against four fungi (Clyptococcus neoformans, Candida glabrata, Trichophyton rubrum, and Aspergillus fumigatus), as well as assessing cytotoxicity against HL-60 and A-549 human cancer cell lines. The compounds studied displayed moderate activities, relative to controls. (c) 2014 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[20862013] ; National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; Natural Science Foundation of Jiangxi Province, China[2010GQY0217] ; State Key Laboratory of Drug Research-SIMM[SIMM1203KF-12] ; China Postdotoral Science Foundation[2012M520956]
WOS关键词	HALOGENATED METABOLITES ; ABSOLUTE-CONFIGURATION ; OBTUSA ; (-)-APLYSIN ; CUPARENE ; (-)-DEBROMOAPLYSIN ; ACETOGENINS ; CERAMIALES ; COMPOSITA ; ETHER
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000337777800020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277015]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Mao, Shui-Chun
作者单位	1.Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Nanchang Univ, Inst Translat Med, Nanchang 330031, Peoples R China
推荐引用方式 GB/T 7714	Yu, Xiao-Qing,He, Wen-Fei,Liu, Ding-Quan,et al. A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada[J]. PHYTOCHEMISTRY,2014,103:162-170.
APA	Yu, Xiao-Qing.,He, Wen-Fei.,Liu, Ding-Quan.,Feng, Mei-Tang.,Fang, Yi.,...&Mao, Shui-Chun.(2014).A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada.PHYTOCHEMISTRY,103,162-170.
MLA	Yu, Xiao-Qing,et al."A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada".PHYTOCHEMISTRY 103(2014):162-170.