AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response

doi:10.1016/j.cellimm.2014.05.008

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 新药研究国家重点实验室

	AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response
	Huang, Juxiang 1,2; Wang, Lin 1,2; Jiang, Minghu 3; Chen, Qingchun 1; Jiang, Zhenfu 4; Feng, Haitao 5
刊名	CELLULAR IMMUNOLOGY
	2014-07
卷号	290 期号:1 页码:102-106
关键词	Anterior gradient homolog 2 (AGR2) Humoral immune response Mechanism Lung adenocarcinoma
ISSN号	0008-8749
DOI	10.1016/j.cellimm.2014.05.008
文献子类	Article
英文摘要	7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC <= -0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease databases, we determined AGR2-mediated lung adenocarcinoma metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1. Thus we proposed AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response. (C) 2014 Elsevier Inc. All rights reserved.
资助项目	National Natural Science Foundation of China[61171114] ; State Key Laboratory of Drug Research[SIMM1302KF] ; Automatical Scientific Planning of Tsinghua University[20111081023] ; Automatical Scientific Planning of Tsinghua University[20111081010] ; Fundamental Research Funds for the Central Universities (BUPT Project)[2014RC0201]
WOS关键词	SYSTEMS-THEORETICAL ANALYSIS ; CYCLE COMPUTATIONAL NETWORK ; HEPATOCELLULAR-CARCINOMA ; ANTERIOR GRADIENT-2 ; PROSTATE-CANCER ; GROWTH ; ALPHA ; AGR2 ; HEPATITIS/CIRRHOSIS ; TRANSFORMATION
WOS研究方向	Cell Biology ; Immunology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000340218300013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276995]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Wang, Lin
作者单位	1.Beijing Univ Posts & Telecommun, Sch Elect Engn, Biomed Ctr, Beijing 100876, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Tsinghua Univ, Sch Humanities & Social Sci, Lab Computat Linguist, Beijing 100084, Peoples R China; 4.China Univ Min & Technol, Sch Mech Elect & Informat Engn, Beijing 100083, Peoples R China; 5.Heilongjiang Univ Chinese Med, Dean Dept, Harbin 150040, Peoples R China
推荐引用方式 GB/T 7714	Huang, Juxiang,Wang, Lin,Jiang, Minghu,et al. AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response[J]. CELLULAR IMMUNOLOGY,2014,290(1):102-106.
APA	Huang, Juxiang,Wang, Lin,Jiang, Minghu,Chen, Qingchun,Jiang, Zhenfu,&Feng, Haitao.(2014).AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.CELLULAR IMMUNOLOGY,290(1),102-106.
MLA	Huang, Juxiang,et al."AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response".CELLULAR IMMUNOLOGY 290.1(2014):102-106.