Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus

doi:10.1021/np500125x

	Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus
	Wu, Zhi-Yuan 1; Zhang, Yi-Bei 1; Zhu, Kong-Kai 2; Luo, Cheng2 ; Zhang, Jing-Xian 1; Cheng, Chun-Ru 1; Feng, Rui-Hong 1; Yang, Wen-Zhi 1; Zeng, Feng 1; Wang, Yang 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2014-11
卷号	77 期号:11 页码:2342-2351
ISSN号	0163-3864
DOI	10.1021/np500125x
文献子类	Article
英文摘要	Five new ent-pimarane (1-3, 7, and 8) and three new ent-kaurane diterpenoids (4-6) and a new oleanane triterpene acid (9), together with 22 known compounds, were isolated from the root bark of the medicinal herb Acanthopanax gracilistylus. The structures of 1-9 were established based on the interpretation of high-resolution MS and 1D- and 2D-NMR data. The absolute configurations of 7 and 11 were determined by single-crystal X-ray diffraction and electronic circular dichroism analysis. Compounds 7 and 8 represent rare naturally occurring structures based on the devinyl ent-pimarane skeleton. Compounds 3, 10, 14, 16, and 17 exhibited potent inhibitory effects on the release of interleukin-1 beta (IL-1 beta), interleukin-8 (IL-8), and tumor necrosis factor (TNF-alpha) in lipopolysaccharide-stimulated peripheral blood mononuclear cells.
资助项目	Twelfth Five-Year National Science & Technology Support Program[2012BAI29B06] ; Major Projects of Knowledge Innovation Program of the Chinese Academy of Sciences[KSCX2-YW-R-166] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2011ZX09307-002-03]
WOS关键词	ENT-KAURANE DITERPENOIDS ; ARALIA-CORDATA ; IN-VITRO ; TERPENE DERIVATIVES ; AGGREGATION ; LEAVES ; DRUGS ; ACID
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000345472100003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276848]
专题	成果转移转化处中科院受体结构与功能重点实验室新药研究国家重点实验室上海中药现代化研究中心
通讯作者	Guan, Shu-Hong
作者单位	1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab Tradit Chinese Med Standardizat Tec, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Zhi-Yuan,Zhang, Yi-Bei,Zhu, Kong-Kai,et al. Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(11):2342-2351.
APA	Wu, Zhi-Yuan.,Zhang, Yi-Bei.,Zhu, Kong-Kai.,Luo, Cheng.,Zhang, Jing-Xian.,...&Guo, De-An.(2014).Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus.JOURNAL OF NATURAL PRODUCTS,77(11),2342-2351.
MLA	Wu, Zhi-Yuan,et al."Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus".JOURNAL OF NATURAL PRODUCTS 77.11(2014):2342-2351.