A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects

doi:10.1111/jnc.13046

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects
	Ruan, Zhi 1; Wang, Hong Min 2; Huang, Xiao Tian 1; Fu, Yan 1; Wu, Jian 2; Ye, Chun Yan 1; Li, Jin Long 2; Wu, Lei 1; Gong, Qi 1; Zhao, Wei Min 2
刊名	JOURNAL OF NEUROCHEMISTRY
	2015-04
卷号	133 期号:1 页码:93-103
关键词	caffeoyl triterpene hypothermia inflammation ischemic stroke neuroprotection therapeutic time window
ISSN号	0022-3042
DOI	10.1111/jnc.13046
文献子类	Article
英文摘要	Despite the intense efforts in searching for stroke therapies, an urgent need still exists to explore novel neuroprotective agents for ischemic stroke that have high efficacy and wide therapeutic time-window. Here, we provide the first demonstration that 28-O-caffeoyl betulin (B-CA), a novel derivative of naturally occurring caffeoyl triterpene, could significantly alleviate brain infarction and neurological deficit when given as late as 6h after transient middle cerebral artery occlusion in the rat. Moreover, post-ischemia B-CA administration exhibited long-term (14days post stroke) protective effects on both brain infarction and functional (i.e., motor and sensory) deficits. Protective B-CA effects correlated with decreased inflammatory responses as indicated by inhibition of microglia and astrocyte activation [stained with ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) antibody, respectively], as well as suppression of tumor necrosis factor-, interleukin-1, and cyclooxygenase-2 overproduction in the ipsilateral cortex of ischemic rat. B-CA administration caused significant hypothermia in the focal cerebral ischemic rat, which may contribute to its ameliorative effects on brain damage and inflammation. In view of its potency in wide therapeutic time-window, robust anti-inflammatory and hypothermic effects, this novel caffeoyl triterpene derivative may lead toward the development of effective therapeutic strategies for the treatment of ischemic stroke.
资助项目	Ministry of Science and Technology of China[2011CB510004] ; National Natural Science Foundation of China[81173034] ; National Natural Science Foundation of China[81473113] ; National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program' of China[2012ZX09301001-004] ; State Key Laboratory of Drug Research[SIMM1403KF-04]
WOS关键词	VANILLOID RECEPTOR TRPV1 ; BRAIN INFLAMMATION ; NEUROVASCULAR PROTECTION ; EXPERIMENTAL STROKE ; BODY-TEMPERATURE ; ARTERY OCCLUSION ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; EXPRESSION ; RATS
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000351393900009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276592]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第二研究室
通讯作者	Zhang, Hai Yan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, CAS Key Lab Receptor Res, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Ruan, Zhi,Wang, Hong Min,Huang, Xiao Tian,et al. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects[J]. JOURNAL OF NEUROCHEMISTRY,2015,133(1):93-103.
APA	Ruan, Zhi.,Wang, Hong Min.,Huang, Xiao Tian.,Fu, Yan.,Wu, Jian.,...&Zhang, Hai Yan.(2015).A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects.JOURNAL OF NEUROCHEMISTRY,133(1),93-103.
MLA	Ruan, Zhi,et al."A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects".JOURNAL OF NEUROCHEMISTRY 133.1(2015):93-103.