Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides

doi:10.1021/acs.orglett.5b00371

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides
	Wu, Jiewei 2,5; Tang, Chunping2,5 ; Chen, Lan 1; Qiao, Yan 3; Geng, Meiyu1 ; Ye, Yang2,4,5
刊名	ORGANIC LETTERS
	2015-04-03
卷号	17 期号:7 页码:1656-1659
ISSN号	1523-7060
DOI	10.1021/acs.orglett.5b00371
文献子类	Article
英文摘要	Dicarabrones A and B, a pair of epimers possessing a new skeleton featuring a cyclopentane ring connecting two sesquiterpene lactone units, were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established on the basis of spectroscopic data and were further confirmed by single-crystal X-ray crystallography. They were presumably biosynthesized from two sesquiterpenoid monomers through a [3 + 2] cycloaddition. Dicarabrones A and B showed moderate effects on HL-60 cells with IC50 values of 9.1 and 8.2 mu M, respectively.
资助项目	National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; National Natural Science Funds for Distinguished Young Scholar[30925043] ; Ministry of Science and Technology[2007DFC31030] ; Ministry of Science and Technology[2010DFA30980] ; Shanghai Commission of Science and Technology[10DZ1972700] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300]
WOS关键词	DONOR-ACCEPTOR CYCLOPROPANES ; CROSS-CYCLOADDITION ; NONCOVALENT INTERACTIONS ; THERMOCHEMICAL KINETICS ; DENSITY FUNCTIONALS ; CONSTRUCTION ; SKELETONS ; 1,1-DIESTERS ; CARBONYLS ; STRATEGY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000352463200010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276576]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Oncol Pharmacol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China; 3.Zhengzhou Univ, Sch Basic Med Sci, Dept Pathophysiol, Zhengzhou 450001, Henan, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wu, Jiewei,Tang, Chunping,Chen, Lan,et al. Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides[J]. ORGANIC LETTERS,2015,17(7):1656-1659.
APA	Wu, Jiewei,Tang, Chunping,Chen, Lan,Qiao, Yan,Geng, Meiyu,&Ye, Yang.(2015).Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides.ORGANIC LETTERS,17(7),1656-1659.
MLA	Wu, Jiewei,et al."Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides".ORGANIC LETTERS 17.7(2015):1656-1659.