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	Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum
	Liao, Hai-Bing1; Lei, Chun1; Gao, Li-Xin2; Li, Jing-Ya2; Li, Jia2; Hou, Ai-Jun1
刊名	ORGANIC LETTERS
	2015-10-16
卷号	17期号:20页码:5040-5043
ISSN号	1523-7060
DOI	10.1021/acs.orglett.5b02515
文献子类	Article
英文摘要	Two enantiomeric pairs of meroterpenoids, (-)- and (+)-rhodonoids A (1a and 1b) and B (2a and 2b), were isolated unprecedentedly from partially racemic mixtures that naturally occurred in Rhododendron capitatum. Their structures were fully determined by spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. Compounds 1a and 1b are the first examples of meromonoterpenes featuring a unique 6/6/6/4 ring system. Compounds 2a and 2b showed PTP1B inhibitory activity.
资助项目	National Natural Science Foundation of China[81222045] ; Shanghai Municipal Education Commission[12SG02] ; Shanghai Education Development Foundation[12SG02]
WOS关键词	TYROSINE-PHOSPHATASE 1B ; ACID ; CONSTITUENTS ; DERIVATIVES ; INHIBITOR ; PROTEIN
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000363225000028
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276359]
专题	国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心
通讯作者	Hou, Ai-Jun
作者单位	1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liao, Hai-Bing,Lei, Chun,Gao, Li-Xin,et al. Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum[J]. ORGANIC LETTERS,2015,17(20):5040-5043.
APA	Liao, Hai-Bing,Lei, Chun,Gao, Li-Xin,Li, Jing-Ya,Li, Jia,&Hou, Ai-Jun.(2015).Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum.ORGANIC LETTERS,17(20),5040-5043.
MLA	Liao, Hai-Bing,et al."Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum".ORGANIC LETTERS 17.20(2015):5040-5043.

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