Cytotoxic tigliane-type diterpenoids from Croton tiglium

doi:10.1016/j.tet.2015.10.070

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Cytotoxic tigliane-type diterpenoids from Croton tiglium
	Zhang, Dong-Dong; Zhou, Bin; Yu, Jin-Hai; Xu, Cheng-Hui; Ding, Jian; Zhang, Hua; Yue, Jian-Min
刊名	TETRAHEDRON
	2015-12-30
卷号	71 期号:52 页码:9638-9644
关键词	Croton tiglium Diterpenoid Tigliane Cytotoxicity
ISSN号	0040-4020
DOI	10.1016/j.tet.2015.10.070
文献子类	Article
英文摘要	Chemical study on the twigs and leaves of Croton tiglium has led to the isolation of 11 new tigliane-type diterpenoids, crotignoids A-K(1-11), along with eight known analogues (12-19). The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. In vitro cytotoxic assays revealed moderate inhibition of compounds 1-10 toward human HL-60 and A549 tumor cells, with 1 exhibiting the strongest activity against HL-60 cell line with an IC50 value of 1.61 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation[81322045]
WOS关键词	PHORBOL ESTERS ; CLERODANE DITERPENOIDS ; PROTEIN-KINASE ; TONKINENSIS ; AGENTS ; EUPHORBIACEAE ; CONSTITUENTS ; INHIBITORS ; LEAVES ; ASSAY
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000366535800008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276280]
专题	天然药物化学研究室中科院受体结构与功能重点实验室期刊编辑部新药研究国家重点实验室分析化学研究室
通讯作者	Zhang, Hua
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dong-Dong,Zhou, Bin,Yu, Jin-Hai,et al. Cytotoxic tigliane-type diterpenoids from Croton tiglium[J]. TETRAHEDRON,2015,71(52):9638-9644.
APA	Zhang, Dong-Dong.,Zhou, Bin.,Yu, Jin-Hai.,Xu, Cheng-Hui.,Ding, Jian.,...&Yue, Jian-Min.(2015).Cytotoxic tigliane-type diterpenoids from Croton tiglium.TETRAHEDRON,71(52),9638-9644.
MLA	Zhang, Dong-Dong,et al."Cytotoxic tigliane-type diterpenoids from Croton tiglium".TETRAHEDRON 71.52(2015):9638-9644.