Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)

doi:10.1039/c5ob02019k

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	Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)
	Zhan, Yang 1; Zhang, Xiao-Wei 2; Xiong, Ying 2; Li, Bo-Liang 2; Nan, Fa-Jun1
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2016
卷号	14 期号:2 页码:747-751
ISSN号	1477-0520
DOI	10.1039/c5ob02019k
文献子类	Article
英文摘要	A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which significantly simplifies the structure and synthesis from commercially available starting materials. Representative compound (-)-3 exhibited potent activity against ACAT2 and greater selectivity for ACAT2 than for ACAT1.
资助项目	National Science and Technology Major Projects for Major New Drugs Innovation and Development[2012ZX09304011] ; National Science and Technology Major Projects for Major New Drugs Innovation and Development[2013ZX09507002] ; National Natural Science Foundation of China[81321092] ; National Natural Science Foundation of China[31470802] ; Ministry of Science and Technology of China[2011CB910900]
WOS关键词	COACHOLESTEROL ACYLTRANSFERASE ; CHEMICAL-MODIFICATION ; DERIVATIVES ; MICE ; COA
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000367343800033
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276271]
专题	国家新药筛选中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Bo-Liang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhan, Yang,Zhang, Xiao-Wei,Xiong, Ying,et al. Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(2):747-751.
APA	Zhan, Yang,Zhang, Xiao-Wei,Xiong, Ying,Li, Bo-Liang,&Nan, Fa-Jun.(2016).Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).ORGANIC & BIOMOLECULAR CHEMISTRY,14(2),747-751.
MLA	Zhan, Yang,et al."Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)".ORGANIC & BIOMOLECULAR CHEMISTRY 14.2(2016):747-751.