Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes

doi:10.1002/hlca.201500231

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes
	Xiong, Juan 1; Huang, Ya 1; Wu, Xi-Ying 1; Liu, Xin-Hua 2; Fan, Hui 3; Wang, Wei 4; Zhao, Yun 3; Yang, Guo-Xun 1; Zhang, Hai-Yan4 ; Hu, Jin-Feng 1
刊名	HELVETICA CHIMICA ACTA
	2016-01
卷号	99 期号:1 页码:83-89
ISSN号	0018-019X
DOI	10.1002/hlca.201500231
文献子类	Article
英文摘要	Nineteen compounds mainly including pyrrole-containing alkaloids and phytosterols were isolated from the EtOH extract of the fermented mycelia of Xylaria nigripes, a precious medicinal fungus known as Wuling Shen in Chinese. On the basis of spectroscopic methods, the structures of the new naturally occurring compounds were determined to be (4S)-3,4-dihydro-4-(4hydroxybenzyl)-3-oxo-1H-pyrrolo[2,1-c][1,4] oxazine-6-carbaldehyde (1), methyl (2S)-2-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-3-(4-hydroxyphenyl) propanoate (2), and 3-{4-[(2R)-(2,3-dihydroxy-3-methylbutoxy] phenyl}-7-hydroxy-4H-chromen4-one (3), respectively. The absolute configurations of 1 and 2 were deduced by the observed Cotton effects in their circular dichroism (CD) spectra, whereas that of the 1,2-diol moiety in 3 was determined using the Snatzke's method. Their biological activities such as neuroprotective, anti-neuroinflammatory, and cytotoxic properties were also reported.
资助项目	NSFC[81273401] ; NSFC[81202420] ; NSFC[21472021] ; Ph.D. Programs Foundation of Ministry of Education (MOE) of China[20120071110049] ; Ph.D. Programs Foundation of Ministry of Education (MOE) of China[20120071120049] ; National Basic Research Program of China (973 Program)[2013CB530700]
WOS关键词	ABSOLUTE-CONFIGURATION ; PYRROLE ALKALOIDS ; LYCIUM-CHINENSE ; FRUITS ; DERIVATIVES ; STEROIDS ; ESTERS ; STEMS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000368587800014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276259]
专题	药理学第二研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Hu, Jin-Feng
作者单位	1.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 2.Fudan Univ, Sch Pharm, Dept Pharmacol, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 3.E China Normal Univ, Key Lab Brain Funct Genom, Minist Educ, Dept Nat Prod Chem Genet Res, 3663 Zhongshan Rd, Shanghai 200062, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Juan,Huang, Ya,Wu, Xi-Ying,et al. Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes[J]. HELVETICA CHIMICA ACTA,2016,99(1):83-89.
APA	Xiong, Juan.,Huang, Ya.,Wu, Xi-Ying.,Liu, Xin-Hua.,Fan, Hui.,...&Hu, Jin-Feng.(2016).Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes.HELVETICA CHIMICA ACTA,99(1),83-89.
MLA	Xiong, Juan,et al."Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes".HELVETICA CHIMICA ACTA 99.1(2016):83-89.