Long Circulation Red-Blood-Cell-Mimetic Nanoparticles with Peptide-Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

doi:10.1002/adfm.201504780

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	Long Circulation Red-Blood-Cell-Mimetic Nanoparticles with Peptide-Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer
	Su, Jinghan 2,3; Sun, Huiping 1,2,3; Meng, Qingshuo 2,3; Yin, Qi2,3 ; Tang, Shan 2,3; Zhang, Pengcheng2,3 ; Chen, Yi2,3 ; Zhang, Zhiwen2,3 ; Yu, Haijun2,3 ; Li, Yaping2,3,4
刊名	ADVANCED FUNCTIONAL MATERIALS
	2016-02-23
卷号	26 期号:8 页码:1243-1252
关键词	biomimetic breast cancer long circulation metastasis nanoparticles tumor penetration
ISSN号	1616-301X
DOI	10.1002/adfm.201504780
文献子类	Article
英文摘要	Limited blood circulation and poor tumor penetration are two main obstacles hampering the clinical translation of conventional nanosized drug delivery systems (NDDS). Here, red-blood-cell (RBC)-mimetic nanoparticles (NPs) with long circulation and peptide-enhanced tumor penetration for treating metastatic breast cancer are reported. The RBC-mimetic NPs are composed of a paclitaxel (PTX)-loaded polymeric core and a hydrophilic RBC vesicle shell. The RBC-mimetic NPs display dramatically elongated blood circulation with an elimination half time of 32.8 h, 5.8-fold higher than that of the parental polymeric NPs (i.e., 5.6 h). Moreover, the experimental results demonstrate that the tumor penetration ability of the RBC-mimetic NPs can be significantly improved by coadministrating with a tumor-penetrating peptide iRGD. Antitumor studies using a metastatic 4T1 breast tumor model show that RBC-mimetic NPs in combination with iRGD significantly inhibit over 90% of the tumor growth and suppress 95% of the lung metastasis, much more efficient than PTX-loaded polymer NP alone or the combination of polymer NPs and iRGD. The results reveal the importance of both long circulation and tumor penetration of nanosized drugs for efficient cancer therapy, which can provide a new insight for NDDS design.
资助项目	National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81270047] ; National Basic Research Program of China[2012CB932502] ; National Basic Research Program of China[2013CB932503]
WOS关键词	RESPONSIVE MICELLES ; DRUG-DELIVERY ; GOLD NANORODS ; THERAPY ; COMBINATION ; DOXORUBICIN ; BIODISTRIBUTION ; RESISTANCE ; PACLITAXEL ; CARRIERS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000371078100011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276139]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Li, Yaping
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China; 4.Yantai Univ, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Su, Jinghan,Sun, Huiping,Meng, Qingshuo,et al. Long Circulation Red-Blood-Cell-Mimetic Nanoparticles with Peptide-Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(8):1243-1252.
APA	Su, Jinghan.,Sun, Huiping.,Meng, Qingshuo.,Yin, Qi.,Tang, Shan.,...&Li, Yaping.(2016).Long Circulation Red-Blood-Cell-Mimetic Nanoparticles with Peptide-Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,26(8),1243-1252.
MLA	Su, Jinghan,et al."Long Circulation Red-Blood-Cell-Mimetic Nanoparticles with Peptide-Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 26.8(2016):1243-1252.