Advances in development of fluorescent probes for detecting amyloid-beta aggregates

doi:10.1038/aps.2015.155

	Advances in development of fluorescent probes for detecting amyloid-beta aggregates
	Xu, Ming-ming 1; Ren, Wen-ming 2; Tang, Xi-can1 ; Hu, You-hong2 ; Zhang, Hai-yan1
刊名	ACTA PHARMACOLOGICA SINICA
	2016-06
卷号	37 期号:6 页码:719-730
关键词	Alzheimer's disease diagnostic biomarker amyloid-beta optical imaging near-infrared fluorescent probes
ISSN号	1671-4083
DOI	10.1038/aps.2015.155
文献子类	Review
英文摘要	With accumulating evidence suggesting that amyloid-beta (A beta) deposition is a good diagnostic biomarker for Alzheimer's disease (AD), the discovery of active A beta probes has become an active area of research. Among the existing imaging methods, optical imaging targeting A beta aggregates (fibrils or oligomers), especially using near-infrared (NIR) fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes (dominant solvent-dependent mode and a novel solvent-independent mode). Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR A beta diagnostic probes.
资助项目	National Natural Science Foundation of China[81522045] ; National Natural Science Foundation of China[81225022]
WOS关键词	SPORADIC ALZHEIMERS-DISEASE ; IN-VIVO DETECTION ; MOLECULAR IMAGING PROBES ; COGNITIVE DECLINE ; CROSS-LINKING ; MOUSE-BRAIN ; PLAQUES ; DEPOSITION ; CURCUMIN ; LOAD
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5722047
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000377281000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276020]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第二研究室
通讯作者	Hu, You-hong; Zhang, Hai-yan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xu, Ming-ming,Ren, Wen-ming,Tang, Xi-can,et al. Advances in development of fluorescent probes for detecting amyloid-beta aggregates[J]. ACTA PHARMACOLOGICA SINICA,2016,37(6):719-730.
APA	Xu, Ming-ming,Ren, Wen-ming,Tang, Xi-can,Hu, You-hong,&Zhang, Hai-yan.(2016).Advances in development of fluorescent probes for detecting amyloid-beta aggregates.ACTA PHARMACOLOGICA SINICA,37(6),719-730.
MLA	Xu, Ming-ming,et al."Advances in development of fluorescent probes for detecting amyloid-beta aggregates".ACTA PHARMACOLOGICA SINICA 37.6(2016):719-730.