Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus

doi:10.1021/acs.jnatprod.6b00314

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus
	Li, Jin-Long 1; Wu, Lei 2; Wu, Jian 1; Feng, Hong-Xuan 2; Wang, Hong-Min 1; Fu, Yan 2; Zhang, Ru-Jun 1; Zhang, Hai-Yan2 ; Zhao, Wei-Min1
刊名	JOURNAL OF NATURAL PRODUCTS
	2016-11
卷号	79 期号:11 页码:2774-2779
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.6b00314
文献子类	Article
英文摘要	Three new triterpenoids, celastrusins A-C (1-3), together with 3-O-caffeoyl-alpha-amyrin (4) were isolated from the root bark of Celastrus orbiculatus. Their structures were identified by spectroscopic analysis, X-ray crystallography using Cu K alpha radiation, and the comparison of both observed and reported spectroscopic data. An in vitro bioassay revealed that the caffeoyl triterpenoid esters 1, 3, and 4 possess neuroprotective effects against oxygen-glucose deprivation (OGD) induced SH-SYSY cell damage. Further animal studies indicated that compound 1 significantly reduced brain infarction after transient middle cerebral artery occlusion (MCAO) in rats using a 10 mg/kg (i.v.) dose.
资助项目	National Science and Technology Major Projects for Major New Drugs Innovation and Development[2013ZX09507002] ; National Natural Science Foundation of China[81473113] ; National Natural Science Foundation of China[81522045] ; State Key Laboratory of Drug Research[SIMM1601KF-03] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CA-SIMM0120162019]
WOS关键词	ACUTE ISCHEMIC-STROKE ; TISSUE-PLASMINOGEN ACTIVATOR ; RATS ; INJURY ; SESQUITERPENES ; ASSOCIATION ; DEFICITS ; DISEASE ; SEEDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000394410600002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275820]
专题	药理学第二研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Zhang, Hai-Yan; Zhao, Wei-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Jin-Long,Wu, Lei,Wu, Jian,et al. Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(11):2774-2779.
APA	Li, Jin-Long.,Wu, Lei.,Wu, Jian.,Feng, Hong-Xuan.,Wang, Hong-Min.,...&Zhao, Wei-Min.(2016).Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus.JOURNAL OF NATURAL PRODUCTS,79(11),2774-2779.
MLA	Li, Jin-Long,et al."Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus".JOURNAL OF NATURAL PRODUCTS 79.11(2016):2774-2779.