Crassins A-H, Diterpenoids from the Roots of Croton crassifolius

doi:10.1021/acs.jnatprod.6b00425

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	Crassins A-H, Diterpenoids from the Roots of Croton crassifolius
	Yuan, Qing-Qing 1,2; Tang, Shuai 1; Song, Wei-Bin 1; Wang, Wen-Qiong 1; Huang, Min1 ; Xuan, Li-Jiang1
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-02
卷号	80 期号:2 页码:254-260
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.6b00425
文献子类	Article
英文摘要	Phytochemical investigation of the 70% acetone extract of Croton crassifolius roots afforded eight new diterpenoids, crassins A-H (1-8), and 19 known compounds. The structures of the new compounds were determined by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism, single-crystal X-ray diffraction analysis, comparison with literature data, and biogenetic considerations. Crassins A (1) and B (2) are new ring B rearranged diterpenoids, whereas crassin C (3) is a new ring A-rearranged diterpenoid. Crassin H (8) exhibited selective cytotoxicity against A549 cells (IC50 5.2 mu M) compared with HL-60 cells (IC50 11.8 mu M). The known compound chettaphanin-II exhibited moderate activity against the A549 and HL-60 cell lines (IC50 8.4 and 10.5 mu M, respectively).
资助项目	National Science & Technology major project "Key New Drug Creation and Manufacturing Program"[SIMM1601ZZ-03]
WOS关键词	CLERODANE DITERPENOIDS ; NEOCLERODANE DITERPENOIDS ; COLORIMETRIC ASSAY ; TONKINENSIS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000395046900004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275647]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Xuan, Li-Jiang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Qing-Qing,Tang, Shuai,Song, Wei-Bin,et al. Crassins A-H, Diterpenoids from the Roots of Croton crassifolius[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(2):254-260.
APA	Yuan, Qing-Qing,Tang, Shuai,Song, Wei-Bin,Wang, Wen-Qiong,Huang, Min,&Xuan, Li-Jiang.(2017).Crassins A-H, Diterpenoids from the Roots of Croton crassifolius.JOURNAL OF NATURAL PRODUCTS,80(2),254-260.
MLA	Yuan, Qing-Qing,et al."Crassins A-H, Diterpenoids from the Roots of Croton crassifolius".JOURNAL OF NATURAL PRODUCTS 80.2(2017):254-260.