Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit

	Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit
	Xiong, ZQ; Cheng, DH; Tang, XC
刊名	ACTA PHARMACOLOGICA SINICA
	1998-03
卷号	19 期号:2 页码:128-132
关键词	substantia innominata huperzine A physostigmine cholinesterase inhibitors kainic acid choline acetyltransferase memory maze learning
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the effects of huperzine A an nucleus basalis magnocellularis (NBM) lesion-induced spatial working memory impairment. METHODS: A delayed-non-match-to-sample radial arm maze task was used to study spatial working memory. ?he choline acetyltransferase (ChAT) activity was determined by the conversion of [H-3]acetyl-CoA to [H-3]ACh. RESULTS: Unilateral NBM lesion by kainic acid 0.02 mu mol impaired rat's ability to perform this working memory task as; evidenced by fewer correct choices after different delay intervals and more total errors to complete the task. This behavioral impairment associated with a decrease in the activity of ChAT by about 40% in the ipsilateral cerebral cortex. Huperzine A (0.2 mg . kg(-1) ip 30 min before testing) ameliorated this spatial working memory impairment. Physostigmine (0.2 - 0.3 mg . kg(-1) ip 20 min before testing) also attenuated the NBM lesion-induced memory deficit. CONCLUSION: The integrity of NBM, is critical for spatial working memory processing, and this working memory impairment induced by NBM lesion can be ameliorated by huperzine A and physostigmine.
WOS关键词	ALZHEIMERS-DISEASE ; ACETYLCHOLINESTERASE INHIBITOR
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000072465400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274852]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tang, XC
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Xiong, ZQ,Cheng, DH,Tang, XC. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit[J]. ACTA PHARMACOLOGICA SINICA,1998,19(2):128-132.
APA	Xiong, ZQ,Cheng, DH,&Tang, XC.(1998).Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit.ACTA PHARMACOLOGICA SINICA,19(2),128-132.
MLA	Xiong, ZQ,et al."Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit".ACTA PHARMACOLOGICA SINICA 19.2(1998):128-132.