Moclobemide-induced gynecomastia in rats

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	Moclobemide-induced gynecomastia in rats
	Ma, XC; Wang, Y; Liu, JH; Tu, ZH
刊名	ACTA PHARMACOLOGICA SINICA
	2000-10
卷号	21 期号:10 页码:893-896
关键词	moclobemide toxicity gynecomastia prolactin prolactin receptors rat
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To study the toxic effect of moclobemide on male breast and to elucidate its mechanism of action. METHODS: Routine histopathological analysis was used to diagnose the effect of moclobemide on male breast in mts. Plasma concentrations of estrogen, androgen, and prolactin were measured by a ratioimmunometer and relative receptors of mammary gland tissue were detected immunohistochemically. RESULTS: After 180-d moclobemide treatment, the presence of gynecomastia was 0, 5, 5, 7/10 rats in 0, 60, 240, and 600 mg/kg groups, respectively. After 30-d convalescence, only one rat in 600 mg/kg group got the incidence of gynecomastia. Serum prolactin concentration had a trend to decrease with increasing dose and prolactin receptors in mammary gland were up-regulated. CONCLUSION: Long-term treatment with moclobemide causes gynecomastia in rats, which is reversible. The mechanism of moclobemide-induced gynecomastia may be related to the increase in prolactin receptors in mammary glands.
WOS关键词	A INHIBITOR MOCLOBEMIDE ; LONG-TERM TREATMENT ; MALE BREAST ; SECRETION
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000089725800005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274568]
专题	药物安全性评价中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Tu, ZH
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Ma, XC,Wang, Y,Liu, JH,et al. Moclobemide-induced gynecomastia in rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(10):893-896.
APA	Ma, XC,Wang, Y,Liu, JH,&Tu, ZH.(2000).Moclobemide-induced gynecomastia in rats.ACTA PHARMACOLOGICA SINICA,21(10),893-896.
MLA	Ma, XC,et al."Moclobemide-induced gynecomastia in rats".ACTA PHARMACOLOGICA SINICA 21.10(2000):893-896.