Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)

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	Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)
	Zhang, H ; Yu, C ; Jia, JY ; Leung, SWS ; Siow, YL ; Man, RYK ; Zhu, DY
刊名	ACTA PHARMACOLOGICA SINICA
	2002-12
卷号	23 期号:12 页码:1163-1168
关键词	Salvia miltiorrhiza magnesium tanshinoate B (MTB) high pressure liquid chromatography
ISSN号	1671-4083
文献子类	Article
英文摘要	AIM: To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations. METHODS: Commercially available danshen crude drugs from different sources, as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected. The composition of these danshen samples was analyzed using HPLC. Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone IIA, and cryptotanshinone were determined. In some of these samples, the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method. RESULTS: There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study. The amount of MTB was the highest among the four components measured in the crude drugs. However, the amounts of MTB in all danshen preparations were much lower than those in crude drugs. The 2 lipophilic components, isotanshinone II, and cryptotanshinone, were very low or not detectable in both injection and oral preparations. CONCLUSION: MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources. In view of the variation in the amounts of MTB and other components, improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions.
WOS关键词	MAGNESIUM LITHOSPERMATE-B ; RENAL RESPONSES ; INHIBITION ; RADIX ; RATS ; CONFIRMATION ; RELEASE ; CELLS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:1492419
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000179779100016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274300]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Man, RYK
作者单位	1.Univ Hong Kong, Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China 2.Shanghai Xu Hui Dist Cent Hosp, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhang, H,Yu, C,Jia, JY,et al. Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)[J]. ACTA PHARMACOLOGICA SINICA,2002,23(12):1163-1168.
APA	Zhang, H.,Yu, C.,Jia, JY.,Leung, SWS.,Siow, YL.,...&Zhu, DY.(2002).Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza).ACTA PHARMACOLOGICA SINICA,23(12),1163-1168.
MLA	Zhang, H,et al."Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)".ACTA PHARMACOLOGICA SINICA 23.12(2002):1163-1168.