The cytotoxicity of lingshulol: A comparative study with amphidinol 2 on membrane permeabilizing activities

doi:10.1016/j.toxicon.2007.04.001

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	The cytotoxicity of lingshulol: A comparative study with amphidinol 2 on membrane permeabilizing activities
	Qi, Xin-Ming; Yu, Bo ; Huang, Xiao-Chun ; Guo, Yue-Wei; Zhai, Qing ; Jin, Ren
刊名	TOXICON
	2007-08
卷号	50 期号:2 页码:278-282
关键词	lingshuiol membrane permeability cytotoxicity marine polyhydroxy
ISSN号	0041-0101
DOI	10.1016/j.toxicon.2007.04.001
文献子类	Article
英文摘要	The cytotoxicity of lingshuiol, a novel polyhydroxy compound with a linear carbon-chain isolated from the cultured marine dinoflagellate Amphidinium sp., and that of amphidinol 2 (AM2) was compared with hepatocytes. Both lingshuiol and AM2 were toxic to primary rat hepatocytes with IC50 values of 0.21 and 6.4 mu M, respectively. Meanwhile, lingshuiol or AM2 caused a rapid mitochondrial swelling and leakage of Ca2+, underlying the change in permeability of mitochondria. Cyclosporin A, a specific inhibitor of mitochondrial permeability transition (MPT), could not affect these effects, indicating that CsA-sensitive MPT was not involved in the permeabilizing effects of lingsbuiol or AM2. Sytox green tests further demonstrated that lingshuiol had a much stronger permeabilizing activity than AM2. Taken together, these results disclosed that lingshuiol had potent membrane permeabilizing activities, which might account for its cytotoxic effect. (c) 2007 Elsevier Ltd. All rights reserved.
WOS关键词	AMPHOTERICIN-B ; MARINE DINOFLAGELLATE ; CHANNELS
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000248964400012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273195]
专题	新药研究国家重点实验室中科院受体结构与功能重点实验室
通讯作者	Zhai, Qing
作者单位	1.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China 2.Cent Hosp Minhang Dist, Dept Pharm, Shanghai 201100, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Ruijing Hosp, Dept Pharm, Shanghai 200025, Peoples R China
推荐引用方式 GB/T 7714	Qi, Xin-Ming,Yu, Bo,Huang, Xiao-Chun,et al. The cytotoxicity of lingshulol: A comparative study with amphidinol 2 on membrane permeabilizing activities[J]. TOXICON,2007,50(2):278-282.
APA	Qi, Xin-Ming,Yu, Bo,Huang, Xiao-Chun,Guo, Yue-Wei,Zhai, Qing,&Jin, Ren.(2007).The cytotoxicity of lingshulol: A comparative study with amphidinol 2 on membrane permeabilizing activities.TOXICON,50(2),278-282.
MLA	Qi, Xin-Ming,et al."The cytotoxicity of lingshulol: A comparative study with amphidinol 2 on membrane permeabilizing activities".TOXICON 50.2(2007):278-282.