Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones

doi:10.1016/j.ejmech.2007.09.010

	Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones
	Fan, Houxing 1; Chen, Yilang 1; Jiang, Zhiteng 1; Zhang, Shuhua 2; Zhong, Dafang1 ; Ji, Ruyun 1; Yang, Yushe1
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2008-08
卷号	43 期号:8 页码:1706-1714
关键词	oxazolidinone linezolid antibacterial agents gram-positive organisms
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2007.09.010
文献子类	Article
英文摘要	A new series of oxazolidinones bearing N-linked 5-triazolylmethyl group have been synthesized and their in vitro antibacterial activities (MIC) were evaluated against a spectrum of resistant and susceptible Gram-positive organisms. Some of the analogues in this series displayed activity superior to linezolid and vancomycin. Furthermore, in vivo efficacies and pharmacokinetic properties of the selected compounds were also disclosed herein; the selected compounds showed reasonable bioavailability as well as in vivo efficacy comparable to that of linezolid. (c) 2007 Elsevier Masson SAS. All rights reserved.
资助项目	National Natural Science Foundation of China[20672125]
WOS关键词	RESISTANT STAPHYLOCOCCUS-AUREUS ; ANTIBACTERIAL ACTIVITY ; COMMUNITY ; INFECTIONS ; RBX-7644 ; AGENTS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000259161600015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272850]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yang, Yushe
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Sichuan Ind Inst Antibiot, Chengdu 610051, Peoples R China
推荐引用方式 GB/T 7714	Fan, Houxing,Chen, Yilang,Jiang, Zhiteng,et al. Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2008,43(8):1706-1714.
APA	Fan, Houxing.,Chen, Yilang.,Jiang, Zhiteng.,Zhang, Shuhua.,Zhong, Dafang.,...&Yang, Yushe.(2008).Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,43(8),1706-1714.
MLA	Fan, Houxing,et al."Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 43.8(2008):1706-1714.