Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines

doi:10.1039/c7qo00555e

	Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines
	Liu, Ming-Qing 1,2; Jiang, Tao 1; Chen, Wen-Wen1 ; Xu, Ming-Hua1
刊名	ORGANIC CHEMISTRY FRONTIERS
	2017-11-01
卷号	4 期号:11 页码:2159-2162
ISSN号	2052-4129
DOI	10.1039/c7qo00555e
文献子类	Article
英文摘要	A highly enantioselective Rh-catalyzed addition of arylboronic acids to non-benzofused five-membered cyclic N-sulfonyl alkyl-substituted ketimines has been developed. With simple chiral sulfur-olefin as the ligand, the reaction allows convenient access to a variety of sulfamidates with uniformly excellent enantioselectivities (97-99% ee). The synthetic utility of this protocol was exemplified by rapid asymmetric construction of tetrasubstituted chiral beta-amino alcohols and their derivatives.
资助项目	National Natural Science Foundation of China[21325209] ; National Natural Science Foundation of China[21472205] ; National Natural Science Foundation of China[81521005] ; Shanghai Municipal Committee of Science and Technology[14XD1404400]
WOS关键词	PD(II)-CATALYZED ASYMMETRIC ADDITION ; QUATERNARY CARBON CENTERS ; ALPHA-TERTIARY AMINES ; ARYLBORONIC ACIDS ; EFFICIENT ACCESS ; NUCLEOPHILIC ALLYLATION ; ORGANOBORON REAGENTS ; PHOSPHITE-OLEFIN ; DIENE COMPLEXES ; CHIRAL LIGANDS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000413826400014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272433]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Chen, Wen-Wen; Xu, Ming-Hua
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ming-Qing,Jiang, Tao,Chen, Wen-Wen,et al. Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines[J]. ORGANIC CHEMISTRY FRONTIERS,2017,4(11):2159-2162.
APA	Liu, Ming-Qing,Jiang, Tao,Chen, Wen-Wen,&Xu, Ming-Hua.(2017).Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines.ORGANIC CHEMISTRY FRONTIERS,4(11),2159-2162.
MLA	Liu, Ming-Qing,et al."Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines".ORGANIC CHEMISTRY FRONTIERS 4.11(2017):2159-2162.