EFFECTS OF PSEUDOLARIC ACID-B ON BLOOD FLOWS OF ENDOMETRIUM AND MYOMETRIUM IN PREGNANT RATS

	EFFECTS OF PSEUDOLARIC ACID-B ON BLOOD FLOWS OF ENDOMETRIUM AND MYOMETRIUM IN PREGNANT RATS
	WANG, WC; GU, ZP; KOO, A; CHEN, WS
刊名	ACTA PHARMACOLOGICA SINICA
	1991-09
卷号	12 期号:5 页码:423-425
关键词	PSEUDOLARIC ACID-B FEMALE CONTRACEPTIVE AGENTS ENDOMETRIUM MYOMETRIUM BLOOD FLOW VELOCITY
ISSN号	0253-9756
文献子类	Article
英文摘要	Effects of pseudolaric acid B (PB) on endo- and myo-metrial blood flows were measured by hydrogen gas clearance technique in 336 pentobarbital-anesthetized rats divided into control and 2 medicated groups (ig PB 20 and 30 mg.kg-1 on d 7-9 of pregnancy). Measurements of endo- and myo-metrial blood flows were done on d 7-14 of pregnancy. Results showed that the endo- and myo-metrial blood flows were reduced by 33-66% and 30-65% respectively, vs ig 1% CMC 0.5 ml (P < 0.01). Uterine weight during d 10-14 of pregnancy stopped gain. The systemic arterial pressure remained relatively unchanged. It is concluded that PB causes a significant decrease of blood flow in both endo- and myo-metrium, which is accounted as the most important cause of embryo's death.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	中文
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1991GE60900010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275191]
专题	中国科学院上海药物研究所
通讯作者	WANG, WC
作者单位	CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHA TIN,HONG KONG
推荐引用方式 GB/T 7714	WANG, WC,GU, ZP,KOO, A,et al. EFFECTS OF PSEUDOLARIC ACID-B ON BLOOD FLOWS OF ENDOMETRIUM AND MYOMETRIUM IN PREGNANT RATS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(5):423-425.
APA	WANG, WC,GU, ZP,KOO, A,&CHEN, WS.(1991).EFFECTS OF PSEUDOLARIC ACID-B ON BLOOD FLOWS OF ENDOMETRIUM AND MYOMETRIUM IN PREGNANT RATS.ACTA PHARMACOLOGICA SINICA,12(5),423-425.
MLA	WANG, WC,et al."EFFECTS OF PSEUDOLARIC ACID-B ON BLOOD FLOWS OF ENDOMETRIUM AND MYOMETRIUM IN PREGNANT RATS".ACTA PHARMACOLOGICA SINICA 12.5(1991):423-425.