EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT

	EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT
	XIONG, ZQ; TANG, XC; LIN, JL; ZHU, DY
刊名	ACTA PHARMACOLOGICA SINICA
	1995-01
卷号	16 期号:1 页码:21-25
关键词	HUPERZINE A ISOVANIHUPERZINE A PHYSOSTIGMINE GALANTHAMINE CHOLINESTERASE INHIBITORS SCOPOLAMINE ISOFLUROPHATE COGNITION DISORDERS MEMORY
ISSN号	1671-4083
文献子类	Article
英文摘要	AIM: To study the effects of isovanihuperzine A (IVHA) on cholinesterase and scopolamine-induced memory deficit. METHODS: AChE and BuChE activities were determined by the colorimetric method of Ellman. The K-i value was determined by the plotting method of Lineweaver and Burk. In a behavioral test, rats were trained to perform a radial arm maze task using a partially baited procedure. RESULTS: The anti-AChE activity of IVHA was comparable to huperzine A (Hup-A), and was more potent than those of physostigmine and galanthamine with an IC50 value of 0. 11 mu mol . L(-1). IVHA was a mixed competitive type with a K-i value of 32 nmol . L(-1). It bound to AChE in a reversible man ner. IVHA at a dose of 0. 2 mg . kg(-1) ip significantly reversed scopolamine-induced working memory and reference memory impairments in radial arm maze. CONCLUSION: IVHA is a new potential reversible AChE inhibitor and merits further study as a cognitive enhancer.
WOS关键词	HUPERZINE-A
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	中文
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1995QB49300002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275072]
专题	中国科学院上海药物研究所
通讯作者	XIONG, ZQ
作者单位	CHINESE ACAD PREVENT MED, SHANGHAI INST MAT MED, DEPT PHYTOCHEM, SHANGHAI 200031, PEOPLES R CHINA
推荐引用方式 GB/T 7714	XIONG, ZQ,TANG, XC,LIN, JL,et al. EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT[J]. ACTA PHARMACOLOGICA SINICA,1995,16(1):21-25.
APA	XIONG, ZQ,TANG, XC,LIN, JL,&ZHU, DY.(1995).EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT.ACTA PHARMACOLOGICA SINICA,16(1),21-25.
MLA	XIONG, ZQ,et al."EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT".ACTA PHARMACOLOGICA SINICA 16.1(1995):21-25.