Anti-alpha-fetoprotein activity of L-4-oxalysine

	Anti-alpha-fetoprotein activity of L-4-oxalysine
	Wang, XW; Xu, B
刊名	ASIA PACIFIC JOURNAL OF PHARMACOLOGY
	1996-06
卷号	11 期号:2 页码:25-28
关键词	oxalysine 5-fluorouracil alpha-fetoprotein mouse ascites hepatoma-22 (H-22) cells suppressor T cells MTT-microculture tetrazolium assay one-way mixed lymphocyte reactions
ISSN号	0217-9687
文献子类	Article
英文摘要	Effect of L-4-oxalysine (OXL) on the growth stimulatory action and Ts cell induc tion activity of alpha-fetoprotein (AFP) was studied in vitro. When compared with 5-fluorouracil (5-FU), single treatment of OXL presented a weaker cytotoxic activity against mouse ascites hepatoma-22 (H-22) cells. Moreover, lower concentrations of OXL (less than 25 mu g ml(-1)) had no marked antagonistic action on the growth stimulation of H-22 cells by AFP (100 mu g ml(-1)). But, higher concentrations of OXL (25-100 mu g ml(-1)) could significantly abolish the action of AFP. On the other side, when 12.5 mu g ml(-1) of OXL was used in combination with 3.1 mu g ml(-1) of 5-FU, the percentage of suppression on hepatoma growth stimulated by AFP (50 mu g ml(-1)) was increased to 42.8% from 8.3% (OXL alone) or 20.2% (5-FU alone). When 25 mu g ml(-1) of OXL was combined with 6.3 mu g ml(-1) of 5-FU, the inhibition percentage was increased to 63.1% from 35.7% (OXL alone) or 48.8% (5-FU alone). In addition, it was observed by one-way mixed lymphocyte reactions that OXL (12.5 or 50 mu g ml(-1)) produced an inhibitory action on the activity of suppressor T cells induced by AFP (200 mu g ml(-1)).
WOS关键词	CELLS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	SINGAPORE UNIV PRESS UNIV SINGAPORE
WOS记录号	WOS:A1996VV18100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274976]
专题	中国科学院上海药物研究所
通讯作者	Wang, XW
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	Wang, XW,Xu, B. Anti-alpha-fetoprotein activity of L-4-oxalysine[J]. ASIA PACIFIC JOURNAL OF PHARMACOLOGY,1996,11(2):25-28.
APA	Wang, XW,&Xu, B.(1996).Anti-alpha-fetoprotein activity of L-4-oxalysine.ASIA PACIFIC JOURNAL OF PHARMACOLOGY,11(2),25-28.
MLA	Wang, XW,et al."Anti-alpha-fetoprotein activity of L-4-oxalysine".ASIA PACIFIC JOURNAL OF PHARMACOLOGY 11.2(1996):25-28.