Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice

doi:10.1016/S0014-2999(98)00915-7

	Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice
	Wu, WR ; Zheng, JW ; Li, N ; Bai, HQ ; Zhang, KR ; Li, Y
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	1999-02-05
卷号	366 期号:2-3 页码:261-269
关键词	dihydroetorphine immunosuppression dependence
ISSN号	0014-2999
DOI	10.1016/S0014-2999(98)00915-7
文献子类	Article
英文摘要	The immunomodulatory effects of dihydroetorphine were systematically investigated in subchronically treated mice. In a dose-dependent fashion, dihydroetorphine (total doses at 444.5, 889 and 1778 mu g/kg) lowered the increase of body weight, decreased the weight of the spleen and thymus, weakened the delayed-type hypersensitivity, reduced the generation of antibody-forming cells, inhibited splenic lymphocyte proliferation induced by concanavalin A and lipopolysaccharide, suppressed the production of interleukin-2 in the supernatant of splenocytes induced by concanavalin A, and depleted the ratio of CD4(+) and CD8(+) subpopulations. Moreover, the physical dependence on dihydroetorphine was also evaluated to confirm that the immunosuppression was concomitant with the addiction to thr drug. These results demonstrate that subchronic treatment with dihydroetorphine dose dependently suppresses both humoral and cell-mediated immune function, and that the immunosuppressive effects of dihydroetorphine are much more potent than those of morphine. (C) 1999 Elsevier Science B.V. All rights reserved.
WOS关键词	MORPHINE-INDUCED ALTERATIONS ; MECHANISM ; SUPPRESSION ; SPECIFICITY ; RESPONSES ; RECEPTORS ; OPIATE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000078564000017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274752]
专题	中国科学院上海药物研究所
通讯作者	Wu, WR
作者单位	1.Xian Med Univ, Dept Pharmacol, Xian 710061, Peoples R China 2.Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China 3.Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Wu, WR,Zheng, JW,Li, N,et al. Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,1999,366(2-3):261-269.
APA	Wu, WR,Zheng, JW,Li, N,Bai, HQ,Zhang, KR,&Li, Y.(1999).Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice.EUROPEAN JOURNAL OF PHARMACOLOGY,366(2-3),261-269.
MLA	Wu, WR,et al."Immunosuppressive effects of dihydroetorphine, a potent narcotic analgesic, in dihydroetorphine-dependent mice".EUROPEAN JOURNAL OF PHARMACOLOGY 366.2-3(1999):261-269.