Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients

doi:10.1177/147323000002800608

	Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients
	Lu, DY ; Chen, XL ; Cao, JY ; Li, Z ; Xue, HW ; Luo, LJ ; Xu, B
刊名	JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
	2000-11
卷号	28 期号:6 页码:313-317
关键词	fibrinogen blood fibrinogen concentration cancer chemotherapy tumour pathogenesis
ISSN号	0300-0605
DOI	10.1177/147323000002800608
文献子类	Article
英文摘要	Blood fibrinogen concentrations and glutamic-pyruvic transaminase activities of 66 adult cancer inpatients (aged 22 - 70 years) were determined both before and after one or two chemotherapy regimens. The percentage of hepatoma patients with abnormal blood fibrinogen levels (< 1.5 or > 6.0 g/l) was higher (64.3% of 14 patients) than that in other cancer categories (19.2% of 52 patients). The mean blood fibrinogen concentrations of male (3.5 g/l) and female (4.5 g/l) cancer patients were higher than those previously reported for healthy humans (2.8 and 2.9 g/l, respectively). After chemotherapy, blood fibrinogen concentrations decreased in patients whose primary tumours were surgically removed (from 4.8 to 3.2 g/l) but increased (from 3.0 to 4.8 gn) in those who did not undergo surgery. Glutamic-pyruvic transaminase activities did not appear to be related to blood fibrinogen levels. We conclude that the increase in mean blood fibrinogen levels of cancer patients is probably related to tumour growth. Different mechanisms may operate in patients with hepatoma.
WOS关键词	TUMOR ; COAGULATION ; PROTECTION ; CARCINOMA ; PROSTATE ; CELLS ; LUNG
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	CAMBRIDGE MED PUBL
WOS记录号	WOS:000166089300008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274563]
专题	中国科学院上海药物研究所
通讯作者	Lu, DY
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 200436, Peoples R China 3.Cent Hosp Jing An Dist, Shanghai 200040, Peoples R China
推荐引用方式 GB/T 7714	Lu, DY,Chen, XL,Cao, JY,et al. Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2000,28(6):313-317.
APA	Lu, DY.,Chen, XL.,Cao, JY.,Li, Z.,Xue, HW.,...&Xu, B.(2000).Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,28(6),313-317.
MLA	Lu, DY,et al."Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 28.6(2000):313-317.