Low dose gossypol for male contraception

	Low dose gossypol for male contraception
	Gu, ZP ; Mao, BY ; Wang, YX ; Zhang, RA ; Tan, YZ ; Chen, ZX ; Cao, L ; You, GD ; Segal, SJ
刊名	ASIAN JOURNAL OF ANDROLOGY
	2000-12
卷号	2 期号:4 页码:283-287
关键词	gossypol male contraceptive agents LH FSH testosterone serum potassium
ISSN号	1008-682X
文献子类	Article
英文摘要	Aim: To ascertain whether the side effects of gossypol, hypokalemia and irreversibility, could be avoided on dose reduction. Methods: Seventy-seven male volunteers were divided into 3 groups: control (22 cases); 10 mg gossypol (29 cases) and 12.5 mg (26 cases). Serum levels of testosterone, FSH and LH were measured by RTA and potassium by name photometry. Sperm counts and motility were examined before and regularly after treatment for the evaluation of contraceptive efficacy. Results: The average sperm density and motility started to decrease significantly by the end of month 2 of medication and gradually reached the infertility levels ( < 4 million /mL) in both treated groups. After that the 10 mg group was asked to take the same dose every other day for up to a total observation period of 16-18 months for the maintenance of infertility. Subjects in the 12.5 mg group did not take gossypol any more so as to observe the length of the loading dose required, but in a few, a maintenance dose of 12.5 mg every other day was instituted for a few more months. In both treated groups, none of the spouses was pregnant during the maintenance dose period. Serum levels of potassium, FSH, LH and testosterone were not significantly changed and not a single volunteer complained of myoasthenia. After cessation of drug administration, the semen data returned to pretreatment levels. Conclusion: A regimen with 10 or 12.5 mg of gossypol as the daily loading dose and 35 or 43.75 mg as the weekly maintenance dose could induce infertility in male volunteers without developing hypokalemia or irreversibility.
WOS研究方向	Endocrinology & Metabolism ; Urology & Nephrology
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000166435600008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274552]
专题	中国科学院上海药物研究所
通讯作者	Gu, ZP
作者单位	1.Fudan Univ, Med Ctr, Zhong Shan Hosp, Shanghai 200032, Peoples R China 2.Rockefeller Fdn, Populat Div, New York, NY USA 3.Jing An Dist Cent Hosp, Shanghai 200040, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 5.Shanghai Second Med Univ, Ren Ji Hosp, Shanghai 200001, Peoples R China
推荐引用方式 GB/T 7714	Gu, ZP,Mao, BY,Wang, YX,et al. Low dose gossypol for male contraception[J]. ASIAN JOURNAL OF ANDROLOGY,2000,2(4):283-287.
APA	Gu, ZP.,Mao, BY.,Wang, YX.,Zhang, RA.,Tan, YZ.,...&Segal, SJ.(2000).Low dose gossypol for male contraception.ASIAN JOURNAL OF ANDROLOGY,2(4),283-287.
MLA	Gu, ZP,et al."Low dose gossypol for male contraception".ASIAN JOURNAL OF ANDROLOGY 2.4(2000):283-287.