Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure

doi:10.1097/00005344-200108000-00017

	Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure
	Qiu, CB ; Ding, SS ; Hess, P ; Clozel, JP ; Clozel, M
刊名	JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
	2001-08
卷号	38 期号:2 页码:317-324
关键词	tezosentan endothelin endothelin receptors heart failure myocardia infarction renal hemodynamics
ISSN号	0160-2446
DOI	10.1097/00005344-200108000-00017
文献子类	Article
英文摘要	Congestive heart failure (CHF) is commonly associated with renal dysfunction. The goal of the current study was to evaluate the role of endothelin in the renal dysfunction of experimental CHF by using tezosentan, a potent dual endothelin receptor antagonist. Rats were subjected to coronary artery ligation. Cardiac and renal hemodynamics were assessed after 3-5 weeks, when CHF had developed. Compared with control rats, CHF rats had significantly higher left ventricular end-diastolic pressure (LVEDP), lower mean arterial pressure, and reduced dP/dt(max). CHF rats had severe renal vasoconstriction, as assessed by increased renal vascular resistance (RVR, p < 0.001), decreased renal plasma flow (RPF, p < 0.001), and glomerular filtration rate (GFR, p < 0.001). Filtration fraction rose (p < 0.001). Urine flow rate and sodium excretion were markedly lower. Acute administration of tezosentan induced a marked decrease in LVEDP without change of dP/dt(max) and heart rate. Tezosentan decreased RVR (-43%, p < 0.001) and increased RPF and GFR. Filtration fraction decreased slightly, Tezosentan also increased urine flow rate and sodium excretion. These findings demonstrate that endothelin at least partly mediates the altered renal hemodynamics associated with experimental CHF. Dual endothelin receptor blockade could be useful for the improvement of both cardiac and renal function in CHF.
WOS关键词	NITRIC-OXIDE BLOCKADE ; MYOCARDIAL-INFARCTION ; ANGIOTENSIN-II ; INTRARENAL HEMODYNAMICS ; SIGNAL-TRANSDUCTION ; RAT-KIDNEY ; ANTAGONIST ; HYPERTENSION ; INHIBITION ; RESPONSES
WOS研究方向	Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000170020200017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274464]
专题	中国科学院上海药物研究所
通讯作者	Clozel, M
作者单位	1.Actel Pharmaceut Ltd, Innovat Ctr, CH-4123 Allschwil, Switzerland 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Qiu, CB,Ding, SS,Hess, P,et al. Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2001,38(2):317-324.
APA	Qiu, CB,Ding, SS,Hess, P,Clozel, JP,&Clozel, M.(2001).Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,38(2),317-324.
MLA	Qiu, CB,et al."Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 38.2(2001):317-324.