Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure

doi:10.1016/S0008-6363(01)00558-2

	Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure
	Ding, SS ; Qiu, CB ; Hess, P ; Xi, JF ; Clozel, JP ; Clozel, M
刊名	CARDIOVASCULAR RESEARCH
	2002-03
卷号	53 期号:4 页码:963-970
关键词	endothelins heart failure infarction renal function vasoactive agents
ISSN号	0008-6363
DOI	10.1016/S0008-6363(01)00558-2
文献子类	Article
英文摘要	Objective: Importance of endothelin in mediating the chronic renal alterations of chronic heart failure was studied in rats chronically treated with bosentan after myocardial infarction. Methods: Rats were subjected to coronary artery ligation and were treated for 8 weeks with placebo or bosentan, a dual ETA and ETB receptor antagonist, (similar to100 mg/kg/day) as food admix. Sham-operated rats served as normal controls. Cardiac and renal functions were measured at the end of 8-week treatment. Results: Bosentan significantly reduced the elevated left ventricular end-diastolic pressure (from 26.6+/-3.3 to 11.4+/-2.2 mmHg, P<0.001) and the increased heart-to-body-weight ratio seen in untreated rats with myocardial infarction. Bosentan prevented the marked increase in renal vascular resistance (bosentan, 7.7+/-0.6; untreated, 15.6+/-2.5 mmHg/ml/min; P<0.001). This led to a significant increase in renal plasma flow resulting in a decrease in filtration fraction. Bosentan furthermore increased urinary sodium excretion. Conclusions: Prolonged ET receptor blockade in rats with myocardial infarction has chronic renal vasodilatory effect and improves renal sodium excretory function. Thus, dual ET antagonists such as bosentan might be useful in the treatment of the progressive renal failure associated with human chronic heart failure. (C) 2002 Elsevier Science B.V. All rights reserved.
WOS关键词	CONVERTING ENZYME-INHIBITION ; NITRIC-OXIDE BLOCKADE ; ANGIOTENSIN-II ; MYOCARDIAL-INFARCTION ; SIGNAL-TRANSDUCTION ; HEMODYNAMICS ; ANTAGONIST ; BOSENTAN ; KIDNEY ; HYPERTENSION
WOS研究方向	Cardiovascular System & Cardiology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000175316800018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274379]
专题	中国科学院上海药物研究所
通讯作者	Clozel, M
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 2.Actelion Pharmaceut Ltd, CH-4123 Allschwil, Switzerland
推荐引用方式 GB/T 7714	Ding, SS,Qiu, CB,Hess, P,et al. Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure[J]. CARDIOVASCULAR RESEARCH,2002,53(4):963-970.
APA	Ding, SS,Qiu, CB,Hess, P,Xi, JF,Clozel, JP,&Clozel, M.(2002).Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure.CARDIOVASCULAR RESEARCH,53(4),963-970.
MLA	Ding, SS,et al."Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure".CARDIOVASCULAR RESEARCH 53.4(2002):963-970.