Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

doi:10.1016/j.bmcl.2003.10.026

	Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
	Ma, DWW ; Wu, WG ; Yang, GX ; Li, JY; Li, H ; Ye, QH
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2004-01-05
卷号	14 期号:1 页码:47-50
关键词	MMP inhibitors synthesis
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2003.10.026
文献子类	Article
英文摘要	The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups. (C) 2003 Elsevier Ltd. All rights reserved.
WOS关键词	FIBROBLAST COLLAGENASE ; MMP INHIBITORS ; GELATINASE-A ; DESIGN ; DISCOVERY ; PROTEINASE ; EXPRESSION ; THERAPY
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000187862000007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274121]
专题	中国科学院上海药物研究所
通讯作者	Ma, DWW
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ma, DWW,Wu, WG,Yang, GX,et al. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2004,14(1):47-50.
APA	Ma, DWW,Wu, WG,Yang, GX,Li, JY,Li, H,&Ye, QH.(2004).Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,14(1),47-50.
MLA	Ma, DWW,et al."Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14.1(2004):47-50.