Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats

doi:10.1097/01.HP.0000156956.42935.28

	Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats
	Fukuda, S ; Iida, H ; Ikeda, M ; Yan, XM ; Xie, YY
刊名	HEALTH PHYSICS
	2005-07
卷号	89 期号:1 页码:81-88
关键词	uranium depleted toxicity chemical rat chelation
ISSN号	0017-9078
DOI	10.1097/01.HP.0000156956.42935.28
文献子类	Article
英文摘要	We examined the acute toxicity of uranium (99.3% U-238, 0.7 % U-235) and the effects of Catechol-3,6-bis(methyleiminodiacetic acid) (CBMIDA) and Ethane-1-hydroxyl,1-bisphosphonate (EHBP) on the removal of uranium after intramuscular injection as a simulated wound intake in rats. In this experiment, male Wistar rats, 8 wk old, were injected intramuscularly with uranyl nitrate in the femoral muscles. Experiment I: Rats died from 3 to 7 d after they were injected with five doses of 7.9, 15.8, 31.5, 63, and 126 mg kg(-1) uranium. The uranium retained 8.4-13.6% of the injected doses in the kidneys, showing the relationship between the injected dose and the retained concentration (r = 0.997). The excretion rates of the injected doses in the 63 and 126 mg kg(-1) uranium-injected rats were 1.73 % and 3.09 % in urine and 0.81 % and 1.06 % in feces on the first day, and 0.54% and 0.56% in feces on the second day, respectively. Experiment H. The retention of uranium at 1, 3, 6, and 24 h was examined after rats were injected with 63 mg kg(-1) uranium. The concentration of uranium decreased in the plasma, while it increased in the kidneys and femur until 6 h, and it continued to increase in the liver until 24 h. Experiment III. Rats were divided into four groups (n = 10) and were injected with a dose of 2 mg kg(-1) uranium. Two of the groups were then injected intraperitoneally with 240 or 480 mg kg(-1) CBMIDA, and one group was injected with 10 mg kg(-1) EHBP once daily for 28 d, beginning 1 h after uranium injection on the first day. The fourth group was the non-treated control group. The survival rates at the end of the experiment were 80% and 40% in the 240 and 480 mg kg(-1) CBMIDA groups, 50% in the EHBP group, and 20% in the non-treated group. The successive administration of chelating agents was effective in decreasing the concentration of uranium in the kidneys, bone, and liver. The results indicated that uranium induces acute death and renal dysfunction by chemical toxicity, and both CBMIDA and EHBP were effective agents to prevent these effects.
WOS关键词	IN-VIVO CHELATION ; DEPLETED URANIUM ; ORAL URANIUM ; EFFICACY ; EXCRETION ; MICE ; DECORPORATION ; INTOXICATION ; RETENTION ; AGENTS
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000229920300007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273846]
专题	中国科学院上海药物研究所
通讯作者	Fukuda, S
作者单位	1.Natl Inst Radiol Sci, Int Space Radiat Lab, Chiba 2638555, Japan 2.Natl Inst Radiol Sci, Res Ctr Radiat Emergency Med, Chiba 2638555, Japan 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Fukuda, S,Iida, H,Ikeda, M,et al. Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats[J]. HEALTH PHYSICS,2005,89(1):81-88.
APA	Fukuda, S,Iida, H,Ikeda, M,Yan, XM,&Xie, YY.(2005).Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats.HEALTH PHYSICS,89(1),81-88.
MLA	Fukuda, S,et al."Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats".HEALTH PHYSICS 89.1(2005):81-88.