Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods

doi:10.1021/np070247a

	Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods
	Pu, Jian-Xin ; Huang, Sheng-Xiong ; Ren, Jie ; Xiao, Wei-Lie ; Li, Li-Mei ; Li, Rong-Tao ; Li, Liang-Bo ; Liao, Tou-Gen ; Lou, Li-Guang; Zhu, Hua-Jie
刊名	JOURNAL OF NATURAL PRODUCTS
	2007-11
卷号	70 期号:11 页码:1706-1711
ISSN号	0163-3864
DOI	10.1021/np070247a
文献子类	Article
英文摘要	Four new triterpenoids, kadlongilactones C-F (2-5), containing a consecutive hexacyclic [7,7,5,6,6,6] ring system, were isolated from the leaves and stems of Kadsura longipedunculata. In comparison with the NMR data of kadlongilactones A (1) and D (3), a significant phenomena was discovered that ring D of 3 inverted from a half-chair in 1 to a half-boat conformation when the HO-16 group changed from alpha- to beta-orientation. The structures of 2-5 were established on the basis of detailed spectroscopic analysis, and DFT computational methods were applied in the structural validation of compounds 3 and 5. Compounds 1-4 showed significant cytotoxicity against A549, HT-29, and K562 cell lines with IC50 values of 0.49-3.61 mu M in vitro.
WOS关键词	ANTI-HIV ACTIVITY ; SCHISANDRA-LANCIFOLIA ; COMPLETE PREDICTION ; ORGANIC-MOLECULES ; UNIQUE SKELETON ; NORTRITERPENOIDS ; TRITERPENE
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000251179000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273126]
专题	中国科学院上海药物研究所
通讯作者	Zhu, Hua-Jie
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Beijing 200332, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Pu, Jian-Xin,Huang, Sheng-Xiong,Ren, Jie,et al. Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(11):1706-1711.
APA	Pu, Jian-Xin.,Huang, Sheng-Xiong.,Ren, Jie.,Xiao, Wei-Lie.,Li, Li-Mei.,...&Sun, Han-Dong.(2007).Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods.JOURNAL OF NATURAL PRODUCTS,70(11),1706-1711.
MLA	Pu, Jian-Xin,et al."Isolation and structure elucidation of kadlongilactones C-F from kadsura longipedunculata by NMR spectroscopy and DFT computational methods".JOURNAL OF NATURAL PRODUCTS 70.11(2007):1706-1711.