Vitro antitumor activity and synthesis of the key intermediate of bakuchiol

	Vitro antitumor activity and synthesis of the key intermediate of bakuchiol
	Chen, Hong-li; Feng, Hui-jin; Li, Yuan-chao
	2010-04
卷号	45
期号	4
页码	467-70
英文摘要	The in vitro antitumor activity of bakuchiol was exploited, compared with tamoxifen. The result of biological activities showed that bakuchiol could inhibit human breast cancer and the IC50 values were 2.89 x 10(-5) mol L(-1) and 8.29 x 10(-3) mol L(-1) against the cells line T-47D and MDA-MB-231 respectively. On the other hand, the key intermediate to synthesize bakuchiol was obtained by the method of Ireland-Claisen rearrangement. Comparing with traditional Claisen rearrangement, the reaction conditions are milder and the reaction reagents are safer.
会议录	Yao xue xue bao = Acta pharmaceutica Sinica
文献子类	Article;Meeting Abstract
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266932]
专题	中国科学院上海药物研究所
作者单位	Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Chen, Hong-li,Feng, Hui-jin,Li, Yuan-chao. Vitro antitumor activity and synthesis of the key intermediate of bakuchiol[C]. 见:.