Effects of dimercaptosuccinic acid per os on copper excretion in rat

	Effects of dimercaptosuccinic acid per os on copper excretion in rat
	Yan, X M; Li, L; Liang, Y Y; Tao, Z Q; Xu, X H; Chen, Z J; Zhang, J S
	1993-11
卷号	14 Suppl
页码	S34-7
英文摘要	After dimercaptosuccinic acid (DMSA) was given intragastrically by gavage (ig) 0, 250, or 500 mg.kg-1 following in CuSO4 30 mg.kg-1 daily x 3 d in rats, the Cu contents of serum increased markedly within 1-12 h. When ig DMSA daily x 3 d, the excretion of Cu in urine per 24 h in the treated group was greatly promoted vs the control (P < 0.01), that in the 250 or 500 mg.kg-1 group were enhanced 2.4-3.8 and 5.8-7.8 times, respectively. That the excretion of Cu was increased in bile but not in feces suggested the plausible existence an enterohepatic circulation.
会议录	Zhongguo yao li xue bao = Acta pharmacologica Sinica
文献子类	Meeting Abstract;Article
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266924]
专题	中国科学院上海药物研究所
作者单位	Shanghai Institute of Materia Medica, Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Yan, X M,Li, L,Liang, Y Y,et al. Effects of dimercaptosuccinic acid per os on copper excretion in rat[C]. 见:.