Natural neuro-inflammatory inhibitors from Caragana turfanensis

doi:10.1016/j.bmcl.2017.08.047

	Natural neuro-inflammatory inhibitors from Caragana turfanensis
	Song, Yan 1,6; Pan, Lan 2; Li, Wenjie 3; Si, Yingying 1,6; Zhou, Di 1,6; Zheng, Chengjian 5; Hao, Xiaofang 1,6; Jia, Xinyue 2; Jia, Yuemei 2; Shi, Minghui 2
刊名	Bioorganic & medicinal chemistry letters
	2017-10-15
卷号	27 期号:20 页码:4765-4769
ISSN号	1464-3405
DOI	10.1016/j.bmcl.2017.08.047
文献子类	Article
英文摘要	Because of the critical role of over-activated microglia in the progress of neurodegenerative diseases, it has been selected as a potential therapeutic target for drug discovery. In order to find natural neuroinflammatory inhibitors, we carried out a bioactivity-oriented phytochemical research of Caragana turfanensis Kom. (Krassn.), which is a folk medicine widely distributed in Xinjiang. As a result, a new coumarin lactone caraganolide A (1) and 35 known components were characterized from the effective extract of C. turfanensis. Furthermore, their anti-neuroinflammatory effects were evaluated in LPS-induced BV2 microglial cells using Griess assay to determine the release of nitric oxide (NO). Compounds 1, 2, 4-6, 9, 13-15, 20, 29 and 30 exhibited significant inhibitory activities and no obvious cytotoxicities were observed at their effective concentrations. It is noteworthy, the new compound caraganolide A (1) (IC 1.01±1.57µM) and 3',7,8-trihydroxy-4'-methoxyisoflavone (5) (IC6.87±2.23µM) exhibited more excellent action than that of positive control minocycline (IC 9.07±0.86μM).
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266770]
专题	中国科学院上海药物研究所
通讯作者	Li, Ning; Hou, Yue
作者单位	1.Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China; 2.Xinjiang Institute of Chinese Materia Medica and Ethnodrug, Xinming Road 9, Urumqi 830002, China; 3.Women And Children's Hospital of Shenyang, Shenyang City, China; 4.College of Life and Health Sciences, Northeastern University, Shenyang 110004, China 5.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; 6.Traditional Chinese Materia Medica Academy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China;
推荐引用方式 GB/T 7714	Song, Yan,Pan, Lan,Li, Wenjie,et al. Natural neuro-inflammatory inhibitors from Caragana turfanensis[J]. Bioorganic & medicinal chemistry letters,2017,27(20):4765-4769.
APA	Song, Yan.,Pan, Lan.,Li, Wenjie.,Si, Yingying.,Zhou, Di.,...&Hou, Yue.(2017).Natural neuro-inflammatory inhibitors from Caragana turfanensis.Bioorganic & medicinal chemistry letters,27(20),4765-4769.
MLA	Song, Yan,et al."Natural neuro-inflammatory inhibitors from Caragana turfanensis".Bioorganic & medicinal chemistry letters 27.20(2017):4765-4769.