Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event | |
Sun, Xiaowei1,2; Sun, Liuquan1,2 | |
刊名 | STATISTICS AND ITS INTERFACE |
2019 | |
卷号 | 12期号:1页码:1-9 |
关键词 | Additive models Marginal mean Recurrent events Semiparametric method Terminal event Treatment effect |
ISSN号 | 1938-7989 |
英文摘要 | Recurrent event data often arise from biomedical studies and a terminal event may preclude further occurrence of recurrent events. In comparing treatments, the marginal mean is frequently of interest, and treatment-specific differences in the mean number of events are often not constant over time. In this article, we propose a semiparametric method to compare treatment-specific recurrent event means by combining an additive hazards model for the terminal event and an additive rates model for the conditional recurrent event rate. The treatment effect is measured by the difference between treatment-specific recurrent event means. Estimation procedures are developed for the measure and the asymptotic properties of the proposed estimators are established. The finite sample performance of the proposed estimators is examined through simulation studies, and an application to a bladder cancer study demonstrates the usefulness of our method. |
资助项目 | National Natural Science Foundation of China[11771431] ; National Natural Science Foundation of China[11690015] ; Key Laboratory of RCSDS, CAS[2008DP173182] |
WOS研究方向 | Mathematical & Computational Biology ; Mathematics |
语种 | 英语 |
出版者 | INT PRESS BOSTON, INC |
WOS记录号 | WOS:000460758600001 |
内容类型 | 期刊论文 |
源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/34193] |
专题 | 应用数学研究所 |
通讯作者 | Sun, Liuquan |
作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Xiaowei,Sun, Liuquan. Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event[J]. STATISTICS AND ITS INTERFACE,2019,12(1):1-9. |
APA | Sun, Xiaowei,&Sun, Liuquan.(2019).Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event.STATISTICS AND ITS INTERFACE,12(1),1-9. |
MLA | Sun, Xiaowei,et al."Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event".STATISTICS AND ITS INTERFACE 12.1(2019):1-9. |
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