Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma

doi:10.1002/advs.201901214

	Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma
	Meng, Xianfu; Zhang, Hua; Zhang, Meng; Wang, Baoming; Liu, Yanyan; Wang, Yan; Fang, Xiangming; Zhang, Jiawen; Yao, Zhenwei; Bu, Wenbo
刊名	ADVANCED SCIENCE
	2019-12-31
关键词	H-2 release HMSN@AB@PEG negative CT contrast agents osteosarcoma tumor acidic microenvironment
DOI	10.1002/advs.201901214
文献子类	Article; Early Access
英文摘要	The current positive computed tomography (CT) contrast agents (PCTCAs) including clinical iodides, present high CT density value (CT-DV). However, they are incapable for the accurate diagnosis of some diseases with high CT-DV, such as osteosarcoma. Because bones and PCTCAs around osteosarcoma generate similar X-ray attenuations. Here, an innovative strategy of negative CT contrast agents (NCTCAs) to reduce the CT-DV of osteosarcoma is proposed, contributing to accurate detection of osteosarcoma. Hollow mesoporous silica nanoparticles, loading ammonia borane molecules and further modified by polyethylene glycol, are synthesized as NCTCAs for the diagnosis of osteosarcoma. The nanocomposites can produce H-2 in situ at osteosarcoma areas by responding to the acidic microenvironment of osteosarcoma, resulting in nearly 20 times reduction of CT density in osteosarcoma. This helps form large CT density contrast between bones and osteosarcoma, and successfully achieves accurate diagnosis of osteosarcoma. Meanwhile, The NCTCAs strategy greatly expands the scope of CT application, and provides profound implications for the precise clinical diagnosis, treatment, and prognosis of diseases.
WOS关键词	NERVOUS-SYSTEM LYMPHOMA ; AMMONIA-BORANE ; UP-CONVERSION ; HEART-DISEASE ; IN-VIVO ; TUMOR ; ANGIOGRAPHY ; DEHYDROGENATION ; LUMINESCENCE ; PERFORMANCE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27526]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Meng, Xianfu,Zhang, Hua,Zhang, Meng,et al. Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma[J]. ADVANCED SCIENCE,2019.
APA	Meng, Xianfu.,Zhang, Hua.,Zhang, Meng.,Wang, Baoming.,Liu, Yanyan.,...&Bu, Wenbo.(2019).Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma.ADVANCED SCIENCE.
MLA	Meng, Xianfu,et al."Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma".ADVANCED SCIENCE (2019).