Magnetic Hyperthermia-Synergistic H2O2 Self-Sufficient Catalytic Suppression of Osteosarcoma with Enhanced Bone-Regeneration Bioactivity by 3D-Printing Composite Scaffolds | |
Dong, Shaojie; Chen, Yu; Yu, Luodan; Lin, Kaili; Wang, Xudong | |
刊名 | ADVANCED FUNCTIONAL MATERIALS |
2019-12-31 | |
关键词 | bone regeneration magnetic hyperthermia nanocatalytic therapy osteosarcoma scaffolds |
ISSN号 | 1616-301X |
DOI | 10.1002/adfm.201907071 |
文献子类 | Article; Early Access |
英文摘要 | Chemotherapy resistance and bone defects caused by surgical excision of osteosarcoma have been formidable challenges for clinical treatment. Although recently developed nanocatalysts based on Fenton-like reactions for catalytic therapy demonstrate high potential to eliminate chemotherapeutic-insensitive tumors, insufficient concentration of intrinsic hydrogen peroxide (H2O2) and low intratumoral penetrability hinder their applications and therapeutic efficiency. The synchronous enriching intratumor H2O2 amount or nanoagents and promoting osteogenesis are intriguing strategies to solve the dilemma in osteosarcoma therapy. Herein, a multifunctional "all-in-one" biomaterial platform is constructed by co-loading calcium peroxide (CaO2) and iron oxide (Fe3O4) nanoparticles into a three-dimensional (3D) printing akermanite scaffold (AKT-Fe3O4-CaO2). The loaded CaO2 nanoparticles act as H2O2 sources to achieve H2O2 self-sufficient nanocatalytic osteosarcoma therapy as catalyzed by coloaded Fe3O4 nanoagents, as well as provide calcium ion (Ca2+) pools to enhance bone regeneration. The synergistic osteosarcoma-therapeutic effect is achieved from both magnetic hyperthermia as-enabled by Fe3O4 nanoparticles under alternative magnetic fields and hyperthermia-enhanced Fenton-like nanocatalytic reaction for producing highly toxic hydroxyl radicals. Importantly, the constructed 3D AKT-Fe3O4-CaO2 composite scaffolds are featured with favorable bone-regeneration activity, providing a worthy base and positive enlightenment for future osteosarcoma treatment with bone defects by the multifunctional biomaterial platforms. |
WOS关键词 | IRON-OXIDE NANOPARTICLES ; MARROW STROMAL CELLS ; OSTEOGENIC DIFFERENTIATION ; PROTEIN ADSORPTION ; CALCIUM-PHOSPHATE ; TUMOR ; THERAPY ; NANOCATALYST ; TOXICITY ; COATINGS |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/27500] |
专题 | 中国科学院上海硅酸盐研究所 |
推荐引用方式 GB/T 7714 | Dong, Shaojie,Chen, Yu,Yu, Luodan,et al. Magnetic Hyperthermia-Synergistic H2O2 Self-Sufficient Catalytic Suppression of Osteosarcoma with Enhanced Bone-Regeneration Bioactivity by 3D-Printing Composite Scaffolds[J]. ADVANCED FUNCTIONAL MATERIALS,2019. |
APA | Dong, Shaojie,Chen, Yu,Yu, Luodan,Lin, Kaili,&Wang, Xudong.(2019).Magnetic Hyperthermia-Synergistic H2O2 Self-Sufficient Catalytic Suppression of Osteosarcoma with Enhanced Bone-Regeneration Bioactivity by 3D-Printing Composite Scaffolds.ADVANCED FUNCTIONAL MATERIALS. |
MLA | Dong, Shaojie,et al."Magnetic Hyperthermia-Synergistic H2O2 Self-Sufficient Catalytic Suppression of Osteosarcoma with Enhanced Bone-Regeneration Bioactivity by 3D-Printing Composite Scaffolds".ADVANCED FUNCTIONAL MATERIALS (2019). |
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