Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors

doi:10.1021/acsbiomaterials.9b01095

	Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors
	Zhuang, Hui; Lin, Rongcai; Liu, Yaqin; Zhang, Meng; Zhai, Dong; Huan, Zhiguang; Wu, Chengtie
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2019-12-30
卷号	5 期号:12 页码:6725
关键词	akermanite scaffolds photo/magnetothermal treatment tumor therapy osteogenic bioactivity
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.9b01095
文献子类	Article
英文摘要	For the postoperative treatment of bone cancer, biomaterials should possess an antitumor effect and simultaneous repair ability of bone defects. Compared with single photothermal treatment or magnetothermal treatment, photo/magnetothermal joint treatment represents a more high-efficient strategy to kill tumor cells. In this work, a 3D-printed bioceramic scaffold with a photo/magnetothermal effect was successfully designed and fabricated, which exhibited the function of killing tumor cells and excellent osteogenic bioactivity, via incorporating an Fe element into akermanite (AKT) bioceramics. After doping with ferric elements, the AKT scaffolds possessed significantly enhanced compressive strength and desirable ferromagnetic property. The ferric elements endowed the AKT scaffolds with excellent photo/magnetothermal effects, and hence the scaffolds could efficiently kill tumor cells in vitro under mild laser power density and magnetic field. In addition, the Fe-doped AKT bioceramic scaffolds significantly promoted cell proliferation and osteogenic differentiation of rabbit bone mesenchymal stem cells as compared with the original AKT scaffolds without Fe elements. The results suggest that Fe-doped bioceramic scaffolds with both photo/magnetothermal effect and in vitro osteogenic bioactivity could be a promising biomaterial for the synergistic therapy of bone cancers.
WOS关键词	IN-VITRO ; PHOTOTHERMAL THERAPY ; IONIC PRODUCTS ; HYPERTHERMIA ; HYDROXYAPATITE ; NANOPARTICLES ; NANOSTRUCTURES ; PROLIFERATION ; BIOMATERIALS ; DISSOLUTION
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27459]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Zhuang, Hui,Lin, Rongcai,Liu, Yaqin,et al. Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(12):6725.
APA	Zhuang, Hui.,Lin, Rongcai.,Liu, Yaqin.,Zhang, Meng.,Zhai, Dong.,...&Wu, Chengtie.(2019).Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(12),6725.
MLA	Zhuang, Hui,et al."Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.12(2019):6725.