Assembled gold nanorods for the photothermal killing of bacteria

doi:10.1016/j.colsurfb.2018.10.060

	Assembled gold nanorods for the photothermal killing of bacteria
	Yang, Tingting; Wang, Donghui; Liu, Xuanyong
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2019
卷号	173 页码:833
关键词	Gold nanorods Photothermal therapy Antibacterial effect Gram-negative bacilli Gram-positive cocci
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2018.10.060
文献子类	Article
英文摘要	Titanium and its alloys are widely used in many clinical applications, but implant-associated infection may lead to implant failure. Because of the increasing concern about antibiotic resistant pathogen, photothermal therapy (PTT) as a new treatment strategy has received considerable attention. In this work, gold nanorods (GNRs) photoexcited by the near-infrared (NIR) light were immobilized on Ti surface by electrostatic surface self-assembly technique. Field emission scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were used to explore the morphology and composition of the GNRs-modified surface. The photothermal temperature of the immobilized GNRs was measured by an infrared thermal imaging system in real time. In vitro study reveal that the prepared GNRs-modified surface exhibits antibacterial activity against four kinds of bacterial strains including both Gram-negative bacilli (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive cocci (Staphylococcus aureus and Staphylococcus epidermidis) under the irradiation of 808 nm laser. Besides, the antibacterial efficiency of the GNRs-modified surface could keep stable after multiple laser exposure. It should be noted that the GNRs-modified surface shows better antibacterial effect against Gram-negative bacilli compared to Gram-positive cocci. Moreover, the GNRs-modified surface has no obvious adverse effect to the osteoblast precursor cells under NIR irradiation. These data demonstrate that the GNRs-modified surface with negligible cytotoxicity and recyclable antibacterial effect provides a favorable model for the translation of photothermal therapy to the clinical application.
WOS研究方向	Biophysics ; Chemistry ; Materials Science
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27437]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Yang, Tingting,Wang, Donghui,Liu, Xuanyong. Assembled gold nanorods for the photothermal killing of bacteria[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,173:833.
APA	Yang, Tingting,Wang, Donghui,&Liu, Xuanyong.(2019).Assembled gold nanorods for the photothermal killing of bacteria.COLLOIDS AND SURFACES B-BIOINTERFACES,173,833.
MLA	Yang, Tingting,et al."Assembled gold nanorods for the photothermal killing of bacteria".COLLOIDS AND SURFACES B-BIOINTERFACES 173(2019):833.