Nano Textured PEEK Surface for Enhanced Osseointegration

doi:10.1021/acsbiomaterials.8b01425

	Nano Textured PEEK Surface for Enhanced Osseointegration
	Ouyang, Liping; Chen, Meiling; Wang, Donghui; Lu, Tao; Wang, Heying; Meng, Fanhao; Yang, Yan; Ma, Jingzhi; Yeung, Kelvin W. K.; Liu, Xuanyong
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2019-03-01
卷号	5 期号:3 页码:1279
关键词	polyetheretherketone nanostructure osseointegration
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.8b01425
文献子类	Article
英文摘要	Polyetheretherketone (PEEK) is widely used in orthopedic and dental applications because of its similar mechanical properties to those of natural bones. However, the inferior osseointegration and bioinertness hamper the clinic application. The surface texture of biomaterials plays an essential role in controlling cell differentiation through affecting the cell-generated physical forces, thus improving the osseointegration of the substrate. In this work, argon PIII and subsequently hydrogen peroxide treatment are applied to construct the nanostructure on the PEEK surface. The in vitro results show that the cell adhesion, collagen secretion, and extracellular matrix (ECM) deposition can be enhanced on both nanostructured surfaces. The in vivo tests exhibit that the surface fabricated by physical-chemical treatment is more favorable for fibrous tissue filtration inhibition and osseointegration than that fabricated by argon PIII only. This work provides a candidate approach for improving the osseointegration ability of PEEK implant by constructing the nanostructure on its surface, which paves the way of applying PEEK in orthopedic and dental applications.
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27302]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Ouyang, Liping,Chen, Meiling,Wang, Donghui,et al. Nano Textured PEEK Surface for Enhanced Osseointegration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(3):1279.
APA	Ouyang, Liping.,Chen, Meiling.,Wang, Donghui.,Lu, Tao.,Wang, Heying.,...&Liu, Xuanyong.(2019).Nano Textured PEEK Surface for Enhanced Osseointegration.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(3),1279.
MLA	Ouyang, Liping,et al."Nano Textured PEEK Surface for Enhanced Osseointegration".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.3(2019):1279.